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Ships within 48 hours · Estimated delivery Aug 14 - Aug 19
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For Your Every Summer RSVP, with Code: SUMMER15
Description
Siglec-15 mFc Chimera Protein, HumanProduct Specification Species Human Accession Q6ZMC9 1 Amino Acid Sequence Phe20 Thr263, with C terminal Mouse Fc Expression System HEK293 Molecular Weight 60 65 kDa(Reducing) Purity 95%, by SDS PAGE under reducing conditions Endotoxin <0. 1EU g Conjugation Unconjugated Tag Mouse Fc Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at less than 1 mg mL according to the size in ultrapure water after rapid
Product Specification
| Species | Human |
| Accession | Q6ZMC9-1 |
| Amino Acid Sequence | Phe20-Thr263, with C-terminal Mouse Fc |
| Expression System | HEK293 |
| Molecular Weight | 60-65 kDa(Reducing) |
| Purity | ＞95%, by SDS-PAGE under reducing conditions |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Mouse Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation . |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
Siglec-15, one of the Sialic acid-binding immunoglobulin-like lectins (Siglecs) and type-1 transmembrane protein, is expressed mainly in human macrophages and dendritic cells. It is comprised of a lysine-containing transmembrane domain, two extracellular immunoglobulin (Ig)-like domains and a short cytoplasmic domain. Siglec-15 is highly conserved in vertebrates and acts as an immunoreceptor. It exerts diverse functions on osteoclast physiology as well as the tumor microenvironment. Unlike most Siglecs, which are inhibitory receptors, it associates with adapter proteins DAP10 and DAP12 via a transmembrane Lys274 residue for signal activation. Siglec-15 interacts with adapter protein DAP12-Syk signaling pathway to regulate the RANKL/RANK-mediated PI3K, AKT, and ERK signaling pathways during osteoclast formation in vitro. More recently, high Siglec-15 was also found to promote osteosarcoma progression via the activation of the DUSP1/MAPK signaling pathway, and hepatocellular carcinoma migration via CD44 interaction, which prevented lysosomal degradation. As Siglec-15 is mutually exclusive to PD-L1, it is now emerging as a novel immune inhibitor for anti-PD-1/PD-L1 resistant patients.
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