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Description
SEK1/MKK4 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen SEK1 MKK4 Synonyms Dual specificity mitogen activated protein kinase kinase 4; MAP kinase kinase 4; MAPKK 4; JNK activating kinase 1; MAPK ERK kinase 4 (MEK 4); SAPK ERK kinase 1 (SEK1); Stress activated protein kinase kinase 1 (SAPK kinase 1; SAPKK 1; SAPKK1); c Jun N terminal kinase kinase 1 (JNKK); JNKK1; MEK4; PRKMK4; SERK1; SKK1; MAP2K4 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession
Product Specification
| Host | Rabbit |
| Antigen | SEK1/MKK4 |
| Synonyms | Dual specificity mitogen-activated protein kinase kinase 4; MAP kinase kinase 4; MAPKK 4; JNK-activating kinase 1; MAPK/ERK kinase 4 (MEK 4); SAPK/ERK kinase 1 (SEK1); Stress-activated protein kinase kinase 1 (SAPK kinase 1; SAPKK-1; SAPKK1); c-Jun N-terminal kinase kinase 1 (JNKK); JNKK1; MEK4; PRKMK4; SERK1; SKK1; MAP2K4 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | P45985 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HEK-293, HeLa, K562, Jurkat, NIH/3T3, mouse brain, C6, rat brain, COS-7 |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:200 | Hu |
Background
SEK1/MKK4 (also known as MAP2K4, MEK4, JNKK1) is a 399-amino-acid dual-specificity protein kinase located on chromosome 17p11.2 that functions as the immediate upstream activator of both JNK and p38 MAPKs in response to diverse extracellular stresses such as osmotic shock, UV radiation, and cytokines; after phosphorylation by upstream MAP3Ks like MEKK1/2, SEK1/MKK4 phosphorylates JNK and p38 on their Thr-Pro-Tyr motifs, thereby linking stress signals to transcriptional and apoptotic programs, and its activity and stability are subjected to negative feedback control through JNK-mediated phosphorylation of the E3 ubiquitin ligase Itch, which then ubiquitinates and targets SEK1/MKK4 for proteasomal degradation .
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