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Description
ATF-4 Recombinant Rabbit mAb (S-471-111)Product Specification Host Rabbit Antigen ATF 4 Synonyms cAMP dependent transcription factor ATF 4; Activating transcription factor 4; Cyclic AMP responsive element binding protein 2; cAMP responsive element binding protein 2; Tax responsive enhancer element binding protein 67; CREB2; TXREB; TaxREB67 Immunogen Recombinant Protein Location Nucleus, Cytoplasm, Cell membrane Accession P18848 Clone Number S 471 111 Antibody Type Recombinant mAb Isotype
Product Specification
| Host | Rabbit |
| Antigen | ATF-4 |
| Synonyms | cAMP-dependent transcription factor ATF-4; Activating transcription factor 4; Cyclic AMP-responsive element-binding protein 2; cAMP-responsive element-binding protein 2; Tax-responsive enhancer element-binding protein 67; CREB2; TXREB; TaxREB67 |
| Immunogen | Recombinant Protein |
| Location | Nucleus, Cytoplasm, Cell membrane |
| Accession | P18848 |
| Clone Number | S-471-111 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| ICC | 1:100 |
Background
ATF-4 is a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. It belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. ATF4 transcription factor is also known to play role in osteoblast differentiation along with RUNX2 and osterix. ATF4 is also involved in the cannabinoid Δ9-tetrahydrocannabinol–induced apoptosis in cancer cells, by the proapoptotic role of the stress protein p8 via its upregulation of the endoplasmic reticulum stress-related genes ATF4, CHOP, and TRB3.
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