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Description
SLC6A1 Recombinant Rabbit mAb, PBS Only (SDT-2424-278)Product Specification Host Rabbit Antigen SLC6A1 Synonyms Sodium and chloride dependent GABA transporter 1; GAT 1; Solute carrier family 6 member 1; GABATR; GABT1; GAT1 Immunogen Synthetic Peptide Location Cell membrane Accession P30531 Clone Number SDT 2424 278 Antibody Type Recombinant mAb Isotype IgG Application IHC P, IF Reactivity Hu, Ms, Rt Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage
Product Specification
| Host | Rabbit |
| Antigen | SLC6A1 |
| Synonyms | Sodium- and chloride-dependent GABA transporter 1; GAT-1; Solute carrier family 6 member 1; GABATR; GABT1; GAT1 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | P30531 |
| Clone Number | SDT-2424-278 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P, IF |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| IF | 1:500 | Rt |
Background
SLC6A1 encodes GAT-1, the principal Na⁺-coupled transporter that clears the inhibitory neurotransmitter GABA from the synaptic cleft by pumping it back into neurons and astrocytes, thereby terminating GABAergic signaling and maintaining excitatory–inhibitory balance throughout the CNS; mutations that misfold GAT-1 or abolish its plasma-membrane trafficking reduce synaptic GABA clearance, causing epilepsy, intellectual disability, autism spectrum disorders, ADHD, and mood dysfunction, whereas chemical or pharmacological chaperones can rescue some variants by restoring correct folding and surface expression.
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