Invivo anti-Mouse CD122 (IL-2Rβ) Recombinant mAb

CD122, also known as the Interleukin-2 Receptor Beta subunit (IL-2Rβ), is a crucial cell surface receptor protein. It is primarily expressed on immune cells such as activated T cells, Natural Killer (NK) cells, and some memory T cells. While CD122 itself cannot bind to its ligands (e.g., IL-2, IL-15) with high affinity, it is an indispensable component of the functional high-affinity receptor complex. It assembles together with the ligand-specific alpha subunit (CD25) and the common gamma chain subunit (CD132), which is responsible for signal transduction. The intracellular domain of CD122 is directly linked to several key signaling pathways, most notably the JAK-STAT pathway. Upon binding with IL-2 or IL-15, it transduces essential signals that promote immune cell proliferation, survival, and functional activation. Consequently, CD122 plays a central role in the initiation, maintenance, and regulation of both adaptive and innate immune responses. Dysfunction of CD122 is closely associated with various pathological processes, including autoimmune diseases, transplant rejection, and tumor immune evasion. This also makes it an important potential therapeutic target for immunotherapies, such as agonist antibodies.