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Description
Topoisomerase II alpha Recombinant Rabbit mAb (S-513-7)Product Specification Host Rabbit Antigen Topoisomerase II alpha Synonyms DNA topoisomerase 2 alpha, TOP2A, TOP2 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession P11388 Clone Number S 513 7 Antibody Type Recombinant mAb Application WB, IHC P, ICC, ICFCM, IP Reactivity Hu Predicted Reactivity Pg Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0.
Product Specification
| Host | Rabbit |
| Antigen | Topoisomerase II alpha |
| Synonyms | DNA topoisomerase 2-alpha, TOP2A, TOP2 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | P11388 |
| Clone Number | S-513-7 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P, ICC, ICFCM, IP |
| Reactivity | Hu |
| Predicted Reactivity | Pg |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC | 1:2000 | |
| ICFCM | 1:500 | |
| ICC | 1:500 | |
| IP | 1:50 |
Background
DNA topoisomerase IIα is a human enzyme encoded by the TOP2A gene. Topoisomerase IIα relieves topological DNA stress during transcription, condenses chromosomes, and separates chromatids. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another. The gene encoding this enzyme functions as the target for several chemotherapy agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.
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