SKU: 38087471941

UBE3A His&Flag Tag Protein, Human

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Description

UBE3A His&Flag Tag Protein, HumanProduct Specification Species Human Synonyms CTCL tumor antigen se37 2, Human papilloma virus E6 associated protein, Oncogenic protein associated protein E6 AP Accession Q05086 2 Amino Acid Sequence Lys2 Leu852, with N terminal10*His Flag

Product Specification


Species Human
Synonyms CTCL tumor antigen se37-2, Human papilloma virus E6-associated protein, Oncogenic protein-associated protein E6-AP
Accession Q05086-2
Amino Acid Sequence

Lys2-Leu852, with N-terminal10*His-Flag HHHHHHHHHHDYKDDDDKKRAAAKHLIERYYHQLTEGCGNEACTNEFCASCPTFLRMDNNAAAIKALELYKINAKLCDPHPSKKGASSAYLENSKGAPNNSCSEIKMNKKGARIDFKDVTYLTEEKVYEILELCREREDYSPLIRVIGRVFSSAEALVQSFRKVKQHTKEELKSLQAKDEDKDEDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGPDDVSVDIDAIRRVYTRLLSNEKIETAFLNALVYLSPNVECDLTYHNVYSRDPNYLNLFIIVMENRNLHSPEYLEMALPLFCKAMSKLPLAAQGKLIRLWSKYNADQIRRMMETFQQLITYKVISNEFNSRNLVNDDDAIVAASKCLKMVYYANVVGGEVDTNHNEEDDEEPIPESSELTLQELLGEERRNKKGPRVDPLETELGVKTLDCRKPLIPFEEFINEPLNEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLKMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM

Expression System Baculovirus-InsectCells
Molecular Weight 95kDa
Purity >90% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag, Flag Tag
Physical Appearance Liquid
Storage Buffer 20mM Tris, 500mM NaCl, 10% Glycerol, 1mM EDTA, 3mM DTT, pH8.0
Reconstitution N.A
Stability & Storage

12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles.

Reference

1.J Biol Chem. 2009 Apr 17;284(16):10537-45.
2.Nucleic Acids Res. 2014 May;42(9):5765-75.Epub 2014 Apr 11.
3.J Biol Chem. 2009 Apr 17;284(16):10537-45. Epub 2009 Feb 20.
4. Mol Endocrinol. 2006 Oct;20(10):2343-54.Epub 2006 Jun 13.

Background

E3 ubiquitin-protein ligase (UBE3A) which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the BMAL1, ARC, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo. It Plays an important role in the regulation of the circadian clock, leading to its proteasomal degradation. UBE3A acts as transcriptional coactivator of progesterone receptor PGR upon progesterone hormone activation and as a regulator of synaptic development by mediating ubiquitination and degradation of ARC.

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SKU: 38087471941

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Natalie T-J
Lake Worth, US
★★★★★ 1
CONTAINS WHEAT!!!
I’m so disgusted and disappointed. I started having issues with build-up & dandruff again, so I ordered a new bottle, remembering how well this used to work for clarifying & healing my scalp. After using it for about 6 weeks the buildup was better, but I had all these swollen, raised areas all over my scalp that were extremely itchy. I figured it was seborrheic dermatitis taking a long time to clear up. Of course, I scrubbed those areas extra well (insert face-palm here). I have an old bottle of it at my parents’ house that I used over Christmas, and I was both flake and itch free. When I came home it started up again, and I noticed my hands were also breaking out again really severely as well. I now know to suspect my personal products. Naturally I went for the non-allergy friendly brands whose ingredients change on a whim first. Nothing. Finally grabbed the shampoo, thinking that couldn’t possibly be it— and to my shock and amazement, it IS. They don’t even try to hide it with different nomenclature. I’d take a picture to show you how badly this tears up my hands, but I literally just got them calmed back down with steroid cream so the visual effect isn’t as impressive. This makes me want to stop using all of their products, which I’ve depended upon rather heavily because of my allergies & sensitivities. I’ve been using various products from Puriya for YEARS because of it being allergy friendly. I’ve even recommended their products to our patients at my natural health practice. We even considered getting a wholesale account to carry them. Now I don’t feel like I can trust ANY of their products.
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Reviewed in the United States on January 7, 2025
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Jaden Allen
Battle Creek, US
★★★★★ 5
4A/4B Hair with Cradles Cap Testimonial
I've had cradles cap since I was a little girl. It's these big flakes of scalp that are itchy and embarrassing and just look terrible when out of control. Plus my hair is thick so it's hard to remove. It can be caused by a mild fungal infection or hormonal imbalance. I've only tried natural remedies because other places would either offer medications or expensive prices for their products and I didn't want that at all. I tried using tea tree oil, that only made it worse because the bacteria feeds on oil, leaving my scalp okay for the first day then tight the next. I tried Head & Shoulders, Dandruff and Sulfur Shampoos but they only lasted so long and dried out my hair terribly. I figured what could I lose trying this, and I'm elated that I purchased it. The ingredients in here are perfect for me, I can't remember a time when my scalp was so clear, clean, and itch-free. No more embarrassment when going out, no more flaky scalp/skin. Paired with my silicone scalp massager, washing my hair and scalp has become a breeze and I've only used it twice! The smell is nice and did I mention that its very moisturizing for my hair, which is hard to come by in shampoos. This product is all-natural and very well made, and for it's price you're getting a great deal! Trust me you won't be disappointed.
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Reviewed in the United States on June 5, 2020
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Elleindeed19
Lexington, US
★★★★★ 5
Amazing Cream! Like Magic for Me!
Somehow I triggered an eczema flare, and this time it hit my face. I had little bumps everywhere, my skin felt extremely dry and painful, and even under my eyebrows was sore. I’d only ever used eczema creams for my body, so I had nothing meant for my face. I searched for a facial option and this had great reviews and photos that made it look like it worked almost instantly. It arrived in one day, and I used it that night. The cream is very smooth, creamy, and incredibly soothing. By the next morning, my face was back to normal. It did sting slightly when I applied it, but only because my skin was so irritated, not because of any harsh ingredients. The relief was almost immediate. My skin felt soft, smooth, and calm again, and all the irritation cleared up like it was never there. It has a pleasant scent and is very moisturizing. Honestly, it felt like magic. This was a true lifesaver in the moment, definitely a face saver. It isn’t inexpensive but at the moment anything that worked would’ve been worth the price. I highly recommend it.
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Reviewed in the United States on February 27, 2026
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Sara V
Lexington, US
★★★★★ 5
Love This Stuff!
I have skin allergies to anything with fragrance, so I get a lot of eczema flare ups. Not only does this not cause flare ups, but it helps soothe any irritation I have on my face. It’s also not too heavy and doesn’t leave a film feeling or cause breakouts like a lot of the other creams I’ve tried with colloidal oatmeal. Really love that they were able to work such a helpful, soothing ingredient into such a nice formula!
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Reviewed in the United States on April 28, 2026
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Stephen Reddy
Bozeman, US
★★★★★ 5
Great product 😎
Im very picky about what products I use , but ever since using this one I really like the way it feels cool on the skin. I would recommend buying this especially if you have Eczema or just looking for something to apply for daily use .
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Reviewed in the United States on June 4, 2026

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