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Description
M6PR Recombinant Rabbit mAb (S-2348-14)Product Specification Host Rabbit Antigen M6PR Synonyms Cation independent mannose 6 phosphate receptor; CI Man 6 P receptor; CI MPR; 300 kDa mannose 6 phosphate receptor (MPR 300); Insulin like growth factor 2 receptor; Insulin like growth factor II receptor (IGF II receptor); M6P IGF2 receptor (M6P IGF2R); CD222; MPRI; IGF2R Immunogen Synthetic Peptide Location Golgi apparatus membrane Accession P11717 Clone Number S 2348 14 Antibody Type
Product Specification
| Host | Rabbit |
| Antigen | M6PR |
| Synonyms | Cation-independent mannose-6-phosphate receptor; CI Man-6-P receptor; CI-MPR; 300 kDa mannose 6-phosphate receptor (MPR 300); Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor (IGF-II receptor); M6P/IGF2 receptor (M6P/IGF2R); CD222; MPRI; IGF2R |
| Immunogen | Synthetic Peptide |
| Location | Golgi apparatus membrane |
| Accession | P11717 |
| Clone Number | S-2348-14 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, IF |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | 293T, HeLa, Jurkat, SK-MEL-28, NIH/3T3, C6 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms, Rt |
| IHC-P | 1:250 | Hu |
| IF | 1:100 | Hu |
Background
M6PR，which stands for Mannose-6-Phosphate Receptor，is a crucial protein in the cellular processes of eukaryotic organisms. It primarily resides in the Golgi apparatus and endosomes. The M6PR has the ability to recognize and bind to mannose-6-phosphate residues that are present on certain lysosomal enzymes. This binding is essential for the proper sorting and transport of these enzymes. When lysosomal enzymes are synthesized in the endoplasmic reticulum and then transported to the Golgi apparatus，they are tagged with mannose-6-phosphate. The M6PR captures these tagged enzymes in the trans-Golgi network and helps to package them into clathrin-coated vesicles. These vesicles then transport the enzymes to the endosomes，where the M6PR releases the enzymes. The enzymes are subsequently delivered to the lysosomes to carry out their functions in breaking down various biomolecules. In addition to its role in intracellular transport，the M6PR also participates in the endocytosis of extracellular molecules that have been modified with mannose-6-phosphate，contributing to the cell's nutrient uptake and waste processing.
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