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Description
LFIT3 Recombinant Rabbit mAb (S-1893-45)Product Specification Host Rabbit Antigen LFIT3 Immunogen Recombinant Protein Location Mitochondrion Accession Q5T765 Clone Number S 1893 45 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample MDA MB 231, Daudi Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from
Product Specification
| Host | Rabbit |
| Antigen | LFIT3 |
| Immunogen | Recombinant Protein |
| Location | Mitochondrion |
| Accession | Q5T765 |
| Clone Number | S-1893-45 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | MDA-MB-231, Daudi |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu |
| IHC-P | 1:50-1:200 | Hu |
Background
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) is a key player in the immune response, particularly in antiviral defense and cellular signaling regulation. It is a member of the IFIT family and interferon-stimulated genes family, with a structure defined by tetratricopeptide repeats (TPRs) that facilitate protein-protein interactions. IFIT3 plays a crucial role in antiviral innate immunity by recognizing viral RNA and activating immune pathways, leading to antiviral responses. It also modulates the intensity and duration of immune responses, influencing processes like apoptosis and cell survival. In addition to its antiviral functions, IFIT3 is involved in cellular biology changes, including cell proliferation, apoptosis, differentiation, and cancer development. For example, in pancreatic ductal adenocarcinoma, high expression of IFIT3 strengthens the anti-apoptotic ability of cancer cells and increases their resistance to chemotherapeutic drugs.
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