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Description
Alexa Fluor® 647 Rat Anti-Mouse CD63 Antibody (S-R667)Product Specification Host Rat Antigen CD63 Synonyms CD63 antigen Location Secreted, Lysosome, Endosome, Cell membrane Accession P41731 Clone Number S R667 Antibody Type Rat mAb Isotype IgG2a,k Application ICFCM Reactivity Ms Positive Sample C57BL 6 mouse bone marrow cells Purification Protein G Concentration 0. 05mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer PBS, 25% Glycerol, 1% BSA, 0. 3% Proclin 300 Stability &
Product Specification
| Host | Rat |
| Antigen | CD63 |
| Synonyms | CD63 antigen |
| Location | Secreted, Lysosome, Endosome, Cell membrane |
| Accession | P41731 |
| Clone Number | S-R667 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | ICFCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse bone marrow cells |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| ICFCM | 5μl per million cells in 100μl volume | Ms |
Background
CD63 is a tetraspanin protein involved in various cellular processes such as cell adhesion, migration, and signal transduction. It is predominantly found on the membranes of late endosomes, multivesicular bodies, and exosomes. As a marker protein of exosomes, CD63 plays a crucial role in cell-to-cell communication, including facilitating the interaction between tumor cells and surrounding cells. Additionally, CD63 is associated with intracellular secretory events in cells like eosinophils, where it is involved in degranulation processes. In some cancers, such as hepatocellular carcinoma, CD63-overexpressing tumor-associated macrophages can drive tumor progression by promoting cancer cell proliferation, migration, and invasion.
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