SKU: 42275063082

Biotinylated EGFR His&Avi Tag Protein, Human

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Description

Biotinylated EGFR His&Avi Tag Protein, HumanProduct Specification Species Human Synonyms ERBB, ERBB1, HER1 Accession P00533 1 Amino Acid Sequence Leu25 Ser645, with C terminal His&Avi tag

Product Specification


Species Human
Synonyms ERBB, ERBB1, HER1
Accession P00533-1
Amino Acid Sequence

Leu25-Ser645, with C-terminal His&Avi tag LEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSGGGSGGGSHHHHHHHHHHGLNDIFEAQKIEWHE

Expression System HEK293
Molecular Weight 95-110kDa
Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Biotin
Tag Avi Tag, His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1. Fadi S. Saadeh: EGFR as a clinical marker in glioblastomas and other gliomas, The International Journal of Biological Markers 2018, Vol. 33(1) 22 -32.

Background

The Epidermal Growth Factor Receptor (EGFR)is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). EGFR is activated after homodimerization or heterodimerization. Heterodimerization is an important mechanism that allows the activation of all EGFR in response to ligand stimulation. The activated EGFR binds to many signaling proteins and stimulates the activation of many signaling pathways. The specificity and potency of intracellular signaling pathways are determined by positive and negative regulators, the specific composition of activating ligand(s), receptor dimer components, and the diverse range of proteins that associate with the tyrosine phosphorylated C-terminal domain of the EGFR.EGFR is overexpressed or mutated in many cancers, especially in breast cancer, ovarian cancer, and non-small cell lung cancer. The overexpression and overactivation of EGFR is correlated with poor prognosis, drug resistance, cancer metastasis, and lower survival rate.

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SKU: 42275063082

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★★★★★ 5
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Reviewed in the United States on September 9, 2019
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Reviewed in the United States on December 31, 2018
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Lexington, US
★★★★★ 2
Bad book for SOA exam, but oh well.
Format: Paperback
While required by Society of Actuaries as the textbook for Short Term Actuarial Models exam, I could not recommend this textbook for any other purposes. Written by two Canadian actuaries, a lot of terms and explanations used in this textbook cannot be transferred into US P&C insurance. It fails to explains insurance's purpose and products effectively and as an intro book with unnecessary sentences to deliver personal thoughts. It is also a mess in following sections on ratemaking and reserving. I cannot sense a flow from this book that guides readers in an approachable manner. Overall, author compromises the size AND the quality.
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Reviewed in the United States on April 3, 2018
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Corderroni
Cuba, US
★★★★★ 5
Buying secondhand is good for the environment
Format: Paperback, Format: Paperback
Buying secondhand is good for the environment. It all reads the same. This book was as expected and arrived quickly, no complaints.
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Reviewed in the United States on May 10, 2023
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Nathan
Massapequa, US
★★★★★ 4
Decent book
Format: Paperback
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