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Description
Armenian hamster Anti-Mouse/Human Helios Antibody (S-R640)Product Specification Host Armenian hamster Antigen Helios Synonyms Zinc finger protein Helios; Ikaros family zinc finger protein 2; IKZF2; ZNFN1A2 Location Nucleus Accession Q9UKS7 P81183 Clone Number S R640 Antibody Type Recombinant mAb Isotype IgG Application ICFCM Reactivity Hu, Ms Positive Sample Human PBMC Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability &
Product Specification
| Host | Armenian hamster |
| Antigen | Helios |
| Synonyms | Zinc finger protein Helios; Ikaros family zinc finger protein 2; IKZF2; ZNFN1A2 |
| Location | Nucleus |
| Accession | Q9UKS7、 P81183 |
| Clone Number | S-R640 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | ICFCM |
| Reactivity | Hu, Ms |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| ICFCM | 1:200 | Hu, Ms |
Background
Helios protein (encoded by the IKZF2 gene) is a member of the Ikaros family of transcription factors and contains multiple zinc finger domains that facilitate DNA binding and the formation of homodimers or heterodimers. It is predominantly expressed in T cells, regulatory T cells (Tregs), certain B cell subsets, and hematopoietic and epithelial tissues. Helios plays a crucial role in T cell activation, proliferation, and the stability and function of Tregs. Additionally, Helios has been identified as a potential biomarker in autoimmune diseases and may influence tumor development by regulating gene expression and modulating cell differentiation and proliferation.
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