SKU: 43420103423

Biotinylated IFN-alpha/beta R1 His&Avi Tag Protein, Human

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Description

Biotinylated IFN-alpha/beta R1 His&Avi Tag Protein, HumanProduct Specification Species Human Synonyms IFNAR1,IFRC,IFNAR,CRF2 1,IFNAR 1,IFN R 1 Accession P17181 1 Amino Acid Sequence Lys28 Lys436 with His&Avi Tag at the C Terminus Expression System HEK293 Molecular Weight 72 95kDa (Reducing) Purity 95% by SDS PAGE & > 90% SEC HPLC Conjugation Biotin Tag Avi Tag, His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the

Product Specification


Species Human
Synonyms IFNAR1,IFRC,IFNAR,CRF2-1,IFNAR-1,IFN-R-1
Accession P17181-1
Amino Acid Sequence

Lys28-Lys436 with His&Avi Tag at the C-Terminus
Expression System HEK293
Molecular Weight

72-95kDa (Reducing)
Purity ＞95% by SDS-PAGE & > 90% SEC-HPLC
Conjugation Biotin
Tag Avi Tag, His Tag
Physical Appearance Lyophilized powder
Storage Buffer

PBS, PH7.4, 5% trehalose
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Constantinescu SN, Croze E, Wang C, Murti A, Basu L, Mullersman JE, Pfeffer LM. Role of interferon alpha/beta receptor chain 1 in the structure and transmembrane signaling of the interferon alpha/beta receptor complex. Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9602-6.
2.Basu L, Yang CH, Murti A, Garcia JV, Croze E, Constantinescu SN, Mullersman JE, Pfeffer LM. The antiviral action of interferon is potentiated by removal of the conserved IRTAM domain of the IFNAR1 chain of the interferon alpha/beta receptor: effects on JAK-STAT activation and receptor down-regulation. Virology. 1998 Mar 1;242(1):14-21.

Background

The interferon-α/β receptor alpha chain (IFNAR1, CD118) is a single-pass transmembrane protein that belongs to the class II cytokine receptor family and contains four fibronectin type-III domains; together with IFNAR2 it forms the type I interferon receptor. Serving as the high-affinity binding site for IFN-α/β, IFNAR1 can also transduce IFN-β signals independently and modulate—sometimes suppress—the Jak-STAT pathway, thereby acting as a critical on/off switch in innate antiviral immunity. Its expression level or mutation at Tyr466 directly affects STAT phosphorylation efficiency, linking IFNAR1 to chronic viral infections, autoimmune disorders and interferon therapy resistance, making it a key biomarker for assessing IFN efficacy and developing targeted immunomodulatory drugs.

Shipping Notes
  • Free Standard Shipping on $100+ Orders to the USA.
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Exchange/Return Notes
  • We offer a 30-day return/exchange service after receiving.
  • Final sale items are not eligible for returns or exchanges.
  • To process your return/exchange, please contact us at [email protected]
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SKU: 43420103423

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Ricardo Rodríguez
Lexington, US
★★★★★ 4
Bold Look with Good Sun Protection, Slightly Big Fit
Color: Matte Black/Black Polarizedarized, Polarization Type: Polarized, Lens Width: 50 Millimeters
I picked up the QUAY Weekender sunglasses in matte black mainly for everyday wear, and they definitely make a statement. The oversized rounded shape stands out and gives a modern, slightly edgy look. The lenses provide solid UV protection, and I’ve found them comfortable to wear for long stretches without eye strain. They are on the larger side, though. If you have a smaller face, they might feel a bit oversized or slide down slightly. The frames feel lightweight but still sturdy enough for regular use. Overall, they’re a stylish pair of shades that balance fashion and function well, especially if you like a bold, oversized design.
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Reviewed in the United States on February 16, 2026
P
Parks N' Tech
Charlottesville, US
★★★★★ 5
Well Made, Fits Well, Comfortable to Wear, Stylish, Good Value
Color: Matte Black/Black Polarizedarized, Polarization Type: Polarized, Lens Width: 50 Millimeters, Color: Matte Black/Black Polarizedarized, Polarization Type: Polarized, Lens Width: 50 Millimeters
These sunglasses are a masterclass in understated elegance, proving that superior quality and timeless design can come in a perfectly proportioned package. They are an exceptional choice for those who value both form and function in their eyewear. The round "Weekender" style is a timeless classic that exudes a sense of both vintage cool and modern sophistication. Unlike the current trend of oversized frames, these sunglasses are a refreshing alternative, with a size that provides a perfect, unobtrusive fit. The frame feels sturdy and well-balanced, a testament to the excellent quality of the materials and craftsmanship. Their sleek appearance is versatile enough to be worn with a casual outfit or to an upscale event. The optical performance is truly outstanding. The polarized lenses are a key feature, as they dramatically reduce glare from reflective surfaces like water, pavement, and car windows, which improves visual clarity and significantly reduces eye strain. Coupled with comprehensive UV protection, the lenses offer crucial eye health benefits without compromising on style. The sunglasses are also incredibly comfortable to wear, with a lightweight feel and a great fit that allows for hours of wear without any discomfort. At a price point of $75, these sunglasses offer an unbeatable value. The combination of high-end optical features, classic style, and premium build quality is typically found in products at a much higher price. The thoughtful inclusion of a soft squeeze pouch case—which is both sleek and highly practical—and a cleansing cloth further enhances the overall value. For their superior optical performance, sophisticated design, and exceptional value, these sunglasses are a highly recommended accessory. They are a functional and fashionable piece that you'll be happy to wear on any occasion, and they stand as a testament to the fact that you don't need to overspend to get a high-quality product.
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Reviewed in the United States on September 4, 2025
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Verified Purchase
Amazon Customer
Draper, US
★★★★★ 2
Glare
Color: Matte Black/Black Polarizedarized, Polarization Type: Polarized, Lens Width: 50 Millimeters
Nice durable frames but lens are very cheap and have a lot of glare.
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Reviewed in the United States on October 19, 2025
R
RedRedHead
Belleville, US
★★★★★ 5
Stylish glasses that are polarized too!
Color: Matte Black/Black Polarizedarized, Polarization Type: Polarized, Lens Width: 50 Millimeters
These sunglasses fit so good on, nice and snug without being too tight, and they’re lightweight. Super comfortable for all day wear Really like the polarized lenses too These sunglasses kinda remind me of my Ray-bans, but these are a bit more stylish. They’re durable feeling too and come tucked into a cloth type pouch
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Reviewed in the United States on November 24, 2025
I
ilo
Alexandria, US
★★★★★ 5
stylish and modern look that pairs well with a variety of outfits
Color: Matte Black/Black Polarizedarized, Polarization Type: Polarized, Lens Width: 50 Millimeters
The Quay Weekender Round Sunglasses offer a stylish and modern look that pairs well with a variety of outfits. The round frame design gives them a classic yet trendy vibe, making them suitable for both casual and more dressed-up occasions. The lenses provide clear vision and a comfortable level of tint, helping to reduce glare in bright conditions while maintaining a crisp view of your surroundings. The build quality feels solid, with sturdy frames that are lightweight enough for extended wear without discomfort. The nose pads and overall fit make them easy to keep in place throughout the day, whether walking around the city, driving, or relaxing outdoors. These sunglasses are versatile and fashionable, making them a great accessory for everyday wear or special outings. Overall, the Quay Weekender Round Sunglasses combine style, comfort, and durability, making them a reliable choice for anyone looking to add a chic and functional pair of shades to their collection.
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Reviewed in the United States on September 27, 2025

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