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Description
Biotinylated LAIR2/CD306 His&Avi Tag Protein, HumanProduct Specification Species Human Synonyms LAIR2, CD306 Accession Q6ISS4 Amino Acid Sequence Gln22 Pro152, with C terminal 8*His&Avi tag QEGALPRPSISAEPGTVISPGSHVTFMCRGPVGVQTFRLEREDRAKYKDSYNVFRLGPSESEARFHIDSVSEGNAGLYRCLYYKPPGWSEHSDFLELLVKESSGGPDSPDTEPGSSAGTVPGTEASGFDAPIEGRMDHHHHHHHHGLNDIFEAQKIEWHE Expression System HEK293 Molecular Weight 20 25kDa Purity >95% by SDS PAGE Endotoxin <1EU g Conjugation Biotin Tag Avi Tag, His Tag Physical Appearance
Product Specification
| Species | Human |
| Synonyms | LAIR2, CD306 |
| Accession | Q6ISS4 |
| Amino Acid Sequence | Gln22-Pro152, with C-terminal 8*His&Avi tag QEGALPRPSISAEPGTVISPGSHVTFMCRGPVGVQTFRLEREDRAKYKDSYNVFRLGPSESEARFHIDSVSEGNAGLYRCLYYKPPGWSEHSDFLELLVKESSGGPDSPDTEPGSSAGTVPGTEASGFDAPIEGRMDHHHHHHHHGLNDIFEAQKIEWHE |
| Expression System | HEK293 |
| Molecular Weight | 20-25kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Biotin |
| Tag | Avi Tag, His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Lebbink R J. et al. (2008) The Soluble Leukocyte-Associated Ig-Like Receptor (LAIR)-2 Antagonizes the Collagen/LAIR-1 Inhibitory Immune Interaction. J Immunol. 180(3): 1662-1669. |
Background
The leukocyte-associated Ig-like receptor-2 (CD306) is an ITIM-containing inhibitory immune receptor, belonging to the Ig superfamily. LAIR-2 is encoded by a gene located in the vicinity of the LAIR-1 gene in the leukocyte receptor complex on human chromosome 19q13.4. The predicted LAIR-2 protein has a single Ig-like domain sharing 84% sequence homology with hLAIR-1, and the molecule lacks a transmembrane and cytoplasmic region suggesting it is a secreted protein. In contrast to hLAIR-1, LAIR-2 has no orthologs in mice or rats. The membrane ligand for LAIR-1 and LAIR-2 was expressed extensively and ligand recognition was of cross-species. LAIR-2 blocked the interaction of LAIR-1 with its ligand but LAIR-1 didn't block the interaction of LAIR-2 with its ligand. LAIR-2 had a higher affinity for collagen than did LAIR-1. LAIR-2 is a more potent antagonist of LAIR-1 function in vivo, while both sLAIR-1 and LAIR-2 are potential biomarkers. Recently shown that recombinant LAIR-2–His is able to interfere with collagen-induced platelet aggregation and that it efficiently inhibits the binding of collagen to glycoprotein VI and von Willebrand factor.
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4.3 ★★★★★
Based on 18 reviews
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Product Reviews
★★★★★ 5
Great for dry skin and the whole family
Size: 19 Ounce (Pack of 1)
We use this at home for everyone, including the kids, and it works really well. We all have pretty dry skin, and this cream keeps it hydrated for hours. I apply it after showering and it leaves the skin soft without feeling greasy. It has no strong scent, doesn’t irritate, and hasn’t caused any breakouts. I also feel comfortable using it on my kids because it’s gentle and effective. The jar lasts a long time since a little goes a long way. I would definitely buy it again.
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Reviewed in the United States on March 28, 2026
★★★★★ 5
Dry Skin Miracle!
Size: 8 Ounce
I have very dry skin, and around my chin and nose, it flakes and turns red, exposing my inner layer of skin due to severe dryness. I could never seem to hydrate it or get rid of the flakiness. I thought it was just my skin at this point, and I could do nothing to solve it. Now, I've never considered using Cerave; I've always heard negative things about it. However, I've never been a makeup person until now, when I want to try to elevate my look (not to mention I'm always in pain from a lack of hydration). The problem is, my skin is so dry that it cracks the makeup, preventing it from setting well on my face.
Another problem is that around my nostrils, the flakiness looks like boogers, nasty. It's incredibly annoying. So I did a little research, and now I'm here. LET ME TELL YOU! This cream is amazing! I love how thick it is, and how a little goes a long way! My face, for the first time in my short life, is not dry! It's not buttery smooth, as in your hand won't glide against my face, but it won't feel the flakiness and roughness of my skin—and that's a game changer! I'm genuinely obsessed with randomly rubbing my face to feel the almost barrier of hydration, especially around my nostrils! I cannot explain the level of amazement I felt when I touched my nostril area to feel practically smooth skin. I felt as if it were a miracle. I've only used it for a week now, keep in mind, and this is how I feel. PLEASE BUY THIS IF YOU'RE LIKE ME! I'M SO HAPPY WITH THIS PURCHASE, AND IT'S WORTH ALL MY MONEY 🙏
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Reviewed in the United States on March 6, 2026
★★★★★ 5
If you use tretinoin this is for you!
Size: 8 Ounce
This moisturizer has been a total game changer for my skin. I’ve been using tretinoin, and my skin became extremely sensitive—dry, irritated, and compromised. After adding this cream into my routine, I noticed a huge difference.
It helped restore my skin barrier, and my skin feels calmer, more hydrated, and much less reactive. The ingredients are simple and gentle, which is exactly what sensitive skin needs—nothing unnecessary or irritating.
I’ve tried much more expensive moisturizers, and honestly, I would pass on them and stick with this. It performs better for me without the high price tag.
I also love how versatile it is—I use it on my face, neck, and body. It’s rich and nourishing without feeling greasy, and it absorbs beautifully.
If you have sensitive skin or are using tretinoin, this is definitely worth it.
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Reviewed in the United States on April 1, 2026
★★★★★ 5
Effective and wonderful-smelling body wash.
I am picky about body wash, especially fragrances, and this one is one of the best. First and foremost, Method is a eco-friendly brand of bath, body and cleaning products that include non-toxic ingredients and no animal testing. Those things are important to me about a brand. This Simply Nourish body wash includes shea butter, rice milk and coconut to soften skin. The scent is very light and soothing - think a little hint of vanilla, lavender and powder. The scent doesn't linger on your skin or interfere with other fragrances you might use - it just smells really great in the shower. No residue left on the skin, just smoothness, cleanliness and softness.
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Reviewed in the United States on April 30, 2026
★★★★★ 5
Outstanding, lightly moisturizing, clean product
Moisturizing, but light...not heavy. Smells like rich, real coconut, but again...not heavy. Lathers well and leaves not residue on skin. I really like the Method body washes and have a bunch of them which I rotate based on the scent I'm in the mood for. This is one of my favorites.
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Reviewed in the United States on May 16, 2026