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Description
RNF43 mFc Chimera Protein, MouseProduct Specification Species Mouse Synonyms RNF43, RING finger protein 43 Accession Q5NCP0 Amino Acid Sequence Ala34 Tyr197, with C terminal mIgG2a Fc Expression System HEK293 Molecular Weight 55 60kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag Mouse Fc Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Mouse |
| Synonyms | RNF43, RING finger protein 43 |
| Accession | Q5NCP0 |
| Amino Acid Sequence | Ala34-Tyr197, with C-terminal mIgG2a Fc |
| Expression System | HEK293 |
| Molecular Weight | 55-60kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Mouse Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1、Radaszkiewicz T. et al. (2021) RNF43 inhibits WNT5A driven signaling and suppresses melanoma invasion. eLife Sciences. 10. |
Background
RNF43 is an E3 ubiquitin ligase and known negative regulator of WNT/β-catenin signaling. We demonstrate that RNF43 is also a regulator of noncanonical WNT5A- induced signaling in human cells. Analysis of the RNF43 interactome using BioID and immunoprecipitation showed that RNF43 can interact with the core receptor complex components dedicated to the noncanonical Wnt pathway such as ROR1, ROR2, VANGL1, and VANGL2. RNF43 triggers VANGL2 ubiquitination and proteasomal degradation and clathrin- dependent internalization of ROR1 receptor and inhibits ROR2 activation. These activities of RNF43 are physiologically relevant and block pro-metastatic WNT5A signaling in melanoma. RNF43 inhibits responses to WNT5A, which results in the suppression of invasive properties of melanoma cells.
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4.6 ★★★★★
Based on 12 reviews
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Product Reviews
★★★★★ 5
Well made and soft
Size: Queen (20" X 30"), Color: 09 - Slate Blue, Number of Items: 2
Very soft pillowcase. Should be wrinkle free. Good value for money.
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Reviewed in the United States on May 20, 2026
★★★★★ 5
Worth the money
Size: King (20" X 36"), Color: 08 - Grayish Purple, Number of Items: 2
Bedsure king size pillow are soft and comfortable. They are very light weight and durable, they wash well with no color fading. The color is beautiful and a good value for the money.
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Reviewed in the United States on March 29, 2026
★★★★★ 5
Why would you want anything else?
Size: Standard (20" X 26"), Color: 02 - White, Number of Items: 2
I don’t know why anyone would want pillow cases that don’t fit the pillow. These are “envelope” style meaning the pillow tucks inside them for a perfect fit—no “leftover” pillowcase sticking out on the end. They’re very soft and cooling and I have so far bought ones for every bed in my house and will be getting more as extras. Highly recommend!
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Reviewed in the United States on May 17, 2026
★★★★★ 3
Very soft
Size: Body (20" X 54"), Color: 06 - Sage Green, Number of Items: 1
The color was perfect. It’s very soft. The only thing that I really don’t like is the finish of the opening, it would be better with a zipper closure.
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Reviewed in the United States on May 13, 2026
★★★★★ 5
Cool, Comfortable, and Worth Every Penny!
Color: Light Gray, Size: Standard
I’m honestly impressed with these pillowcases! From the first night, I could feel the difference—they stay noticeably cool, which is perfect if you tend to sleep hot like I do. The fabric feels silky smooth against the skin without being slippery, and it’s really gentle on both my hair and face.
I’ve also noticed I wake up less sweaty and more comfortable overall. They fit my pillows well and don’t slip off during the night, which is a big plus. After washing, they held up great—no fading, shrinking, or loss of softness.
If you’re looking for pillowcases that actually help keep you cool and comfortable through the night, these are definitely worth it. I’ll be buying more!
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Reviewed in the United States on April 7, 2026