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Description
GMF-β Protein, HumanProduct Specification Species Human Synonyms Glia maturation factor beta, GMF beta Accession P60983 Amino Acid Sequence Ser2 His142 Expression System E. coli Molecular Weight 16 kDa (Reducing) Purity >95% by SDS PAGE and HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Human |
| Synonyms | Glia maturation factor beta, GMF-beta |
| Accession | P60983 |
| Amino Acid Sequence | Ser2-His142 |
| Expression System | E.coli |
| Molecular Weight | 16 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Trends Cell Biol. 2018 Sep;28(9):749-760. |
Background
Glia Maturation Factor beta (GMFB) is a 17 kDa intracellular protein primarily expressed in the brain's glial cells, though it is also present in other tissues. As a member of the actin-depolymerizing factor family, it functions as a crucial intracellular regulator of actin cytoskeleton dynamics and cellular signaling pathways (notably enhancing p38 MAPK and inhibiting ERK). Its dysregulation is a key amplifier of inflammatory responses and oxidative stress, linking it to the pathology of numerous diseases.
GMFB is a major driver in diseases like Alzheimer's, Parkinson's, and Multiple Sclerosis, where it promotes glial activation and cytokine release. It is considered a promising therapeutic target; studies show GMFB deficiency protects against neuroinflammation.
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