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Description
Monkey TL1A/TNFSF15 OneStep ELISA KitProduct Specification Antigen TL1A TNFSF15 Immunogen Recombinant Protein Antibody Type Recombinant mAb Reactivity Mk Purification Protein A Stability & Storage 12 months from date of receipt reconstitution, 2 to 8'C as supplied. Kit Precision Intra assay: 2. 0% Inter assay: 3. 5% Sample type Cell culture supernatant; Serum; Plasma Assay type Sandwich (quantitative) Sensitivity 1. 757 pg mL Range 7. 81 pg mL 500 pg mL Recovery Cell culture supernatant:
Product Specification
| Antigen | TL1A/TNFSF15 |
| Immunogen | Recombinant Protein |
| Antibody Type | Recombinant mAb |
| Reactivity | Mk |
| Purification | Protein A |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8'C as supplied. |
Kit
| Precision | Intra-assay: 2.0%； Inter-assay: 3.5% |
| Sample type | Cell culture supernatant; Serum; Plasma |
| Assay type | Sandwich (quantitative) |
| Sensitivity | 1.757 pg/mL |
| Range | 7.81 pg/mL – 500 pg/mL |
| Recovery | Cell culture supernatant: 113% Serum: 87% Plasma: 94% |
| Assay time | 60 minutes |
| Species reactivity | Mk |
| CROSS REACTIVITY | Hu |
Background
Monkey TL1A, also known as TNFSF15, is a protein belonging to the tumor necrosis factor (TNF) superfamily. It is primarily expressed on the surface of vascular endothelial cells and certain immune cells. This protein functions as a ligand for the death domain receptor 3 (DR3) on lymphocytes. Upon binding, it activates downstream signaling pathways such as NF-κB and MAPK, which promote inflammatory responses. Its primary role is involved in modulating immune functions, including T cell activation and proliferation. Research indicates that TL1A is a key player in the pathogenesis of various chronic inflammatory and autoimmune diseases, particularly those related to vascular inflammation. Consequently, it has been identified as a potential therapeutic target, with monoclonal antibodies against TL1A currently under investigation for treating conditions like inflammatory bowel disease and rheumatoid arthritis.
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