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Description
Rheb Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen Rheb Synonyms GTP binding protein Rheb; Ras homolog enriched in brain; RHEB2; RHEB Immunogen Synthetic Peptide Location Cytoplasm, Lysosome, Endoplasmic reticulum Accession Q15382 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample A549, U 87 MG, SH SY5Y Predicted Reactivity Bv, Dr, Ms, Rt Purification Immunogen Affinity Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | Rheb |
| Synonyms | GTP-binding protein Rheb; Ras homolog enriched in brain; RHEB2; RHEB |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Lysosome, Endoplasmic reticulum |
| Accession | Q15382 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | A549, U-87 MG, SH-SY5Y |
| Predicted Reactivity | Bv, Dr, Ms, Rt |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:200 | Hu |
Background
Rheb protein is a small GTPase that plays a crucial role in regulating cell growth and metabolism. It acts as a key activator of the mTOR (mechanistic target of rapamycin) pathway, which is central to controlling protein synthesis, cell size, and autophagy. When Rheb is bound to GTP, it stimulates mTORC1 activity, promoting anabolic processes that support cell growth and proliferation. Conversely, when it is in its GDP-bound state, mTORC1 is inhibited, allowing cells to shift towards catabolic processes. Rheb is involved in various cellular functions and its dysregulation has been implicated in several diseases, including cancer and neurodegenerative disorders.
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Exchange/Return Notes
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