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Description
Rat IL-6 ELISA KitProduct Specification Species Reactivity Rat Theory This kit adopts double antibody sandwich enzyme linked immunosorbent detection technology. Specific anti rat IL 6 antibodies were pre coated on high affinity enzyme plates. The standard substance, the sample to be tested and the biotinylated detection antibody are added to the well of the enzyme label plate, and after incubation, IL 6 present in the sample binds to the solid phase antibody and the
Product Specification
| Species Reactivity | Rat | |||||||||||||||||||||||||||
| Theory | This kit adopts double antibody sandwich enzyme-linked immunosorbent detection technology. Specific anti-rat IL-6 antibodies were pre-coated on high affinity enzyme plates. The standard substance, the sample to be tested and the biotinylated detection antibody are added to the well of the enzyme label plate, and after incubation, IL-6 present in the sample binds to the solid phase antibody and the detection antibody to form an immune complex. After washing to remove unbound material, horseradish peroxidase-labeled Streptavidin-HRP was added. After washing, a chromogenic substrate is added to protect the color from light. A stop solution was added to stop the reaction, and the absorbance value was measured at a wavelength of 450 nm (reference calibration wavelength of 540 nm or 570 nm). | |||||||||||||||||||||||||||
| Synonym | B cell stimulation factor-2, B-cell differentiation factor, BSF2, BSF-2, BSF2CTL differentiation factor, CDF, HGFHSFIFNB2Hybridoma growth factor, IFNB2, IFN-beta-2, IL6, IL-6, IL-6B-cell stimulation factor 2, interferon beta-2, interleukin 6 (interferon, beta 2), interleukin BSF-2, interleukin-6, MGI-2A, Rat interleukin 6 Elisa kit | |||||||||||||||||||||||||||
| Composition |
Please use it within the validity period of the kit (new and old products are shipped randomly)
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| Background | Interleukin -6 IL-6 ) is a system with α A spiral structure, 22-28kDa It plays an important role in the acute phase of disease, inflammation, hematopoiesis, bone metabolism and cancer exacerbation. A mature person IL-6 have 183 Amino acids, with mice and rats IL-6 have 41% Homology of. IL-6 Internal alternative splicing results in a variety of isomers, some of which exhibit antagonistic properties. Known expression IL-6 The cells comprise CD8+T Cells, fibroblasts, synoviocytes, adipocytes, osteoblasts, megakaryocytes, endothelial cells (under the influence of endothelin), sympathetic neurons, cerebral cortical nerve cells, adrenal medullary chromaffin cells, retinal pigment cells, mast cells, keratinocytes, Langerhans cells, fetal and adult astrocytes, neutrophils, monocytes, eosinophils, colonic epithelial cells, B1B β Cells. IL-6 The production is usually under the control of glucocorticoids, catecholamines and secondary sex steroids and is generally associated with cellular activation. In normal human blood IL-6 In 1pg/mL Within the range, there is a slight increase in menstrual period, a moderate increase in some cancers, and a significant increase after surgery. IL-6 Cellular signaling is initiated by a cell surface heterodimeric receptor complex consisting of a ligand-binding subunit （ IL-6 Receptor) and a signal transduction subunit gp130 Composition. IL-6 Binding to IL-6 IL-6 Receptor with gp130 Combination of and gp130 Dimerization of. gp130 Also CLC CNTF 、 CT-1 、 IL-11 IL-27 、 LIF And OSM IL-6 Receptors are produced by alternative splicing and proteolysis. Through a trans-signaling mechanism, soluble IL-6 IL-6 Receptor complexes can trigger surface deficiency IL-6 gp130 Response of cells. IL-6 gp130 Molecular expression is very broad, and trans-signaling enables a wider range of cell type pairs IL-6 Response of. Soluble gp130 The spliceosome prevents IL-6/IL-6R Trans-signal transduction, but does not prevent other cytokine utilization gp130 Signal transduction of molecules as co-receptors. IL-6 With tumor necrosis factor ( TNF ) and IL-1 The acute inflammatory reaction caused by it plays an almost unique role in fever and acute inflammatory reaction of the liver, and it also plays an important role in the transformation of acute inflammation into acquired immunity or chronic inflammatory diseases. IL-6 Disorders contribute to chronic inflammation in cases such as obesity, insulin resistance, inflammatory bowel disease, inflammatory arthritis, and sepsis, often involving IL-6 TGF- Under the conditions of existence, IL-6 In the naive type T Cells to Th17 It plays an important role in the process of inflammatory cell differentiation. IL-6 Modulates bone resorption, and by promoting Th17 The active component of inflammatory cells is the main factor causing inflammatory joint damage in rheumatoid arthritis I 。 L-6 Contributes to the formation and instability of atherosclerotic plaque. but IL-6 It also has anti-inflammatory effects, such as skeletal muscle secretion during physical exercise IL-6 。 It acts as a hematopoietic stem cell growth factor to promote hematopoiesis, induction B The cells mature into plasma cells, immortalized multiple myeloma cells. IL-6 It also promotes but initiates the development of other inflammation-related cancers, such as enteritis-related cancers. |
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| General Notes | 1. Please use the kit within the validity period. 2. The components of different kits and different batch kits cannot be mixed. 3. If the sample value is greater than the highest value of the standard curve, the sample should be diluted with diluent (1 ×) and re-tested; If the cell culture supernatant sample needs to be distributed and diluted, cell culture medium can be used for other intermediate dilutions except dilution with diluent in the last step. 4. Differences in test results can be caused by a variety of factors, including the operation of the experimenter, the use of the pipette, the plate washing technique, the reaction time or temperature, the storage of the kit, etc. 5. The terminating solution in the kit is an acidic solution. Please protect your glasses, hands, face and clothes when using it. 6. For scientific research only, not for in vitro diagnosis. |
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| Storage Temp. | Unopened kit, store at 2-8°C | |||||||||||||||||||||||||||
| Test Range | 125pg/mL-8000pg/mL |
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4.2 ★★★★★
Based on 29 reviews
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Product Reviews
★★★★★ 5
Longest lasting dog toys we’ve purchased.
Style: Fox, Raccoon, Squirrel
In 2020, we purchased these for our 6 month old puppy who was repeatedly destroying all of her toys. Christmas 2025, I gifted our dog a stuffed toy purchased from a local dog store. It was destroyed within an hour. Later that day, I found one of these little squirrels that we purchased FIVE years ago - still in action, a bit worse for the wear, but still very much loved by our dog. I decided to purchase another pack of these as they are clearly winners.
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Reviewed in the United States on January 19, 2026
★★★★★ 5
Nice toy
Style: Variety Pack - Large (3-pack)
Good idea, no stuffing.
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Reviewed in the United States on May 9, 2026
★★★★★ 3
The Ad got me, the reality didn't
Style: Variety Pack - Large (3-pack)
Directly from the ad- "Exclusive Noisemakers - Each large toy includes 3 high-quality round squeakers to deliver more sound to keep your best friend entertained.". Now my neighbor bought this squirrel with three high-quality squeakers nearly a year ago. It's ragged and tattered I just recently sewed it up for him where he chewed the one leg odd, but those three noise makers are still squeaking. Whe I got my pup, I immediately went to buy one and they were no longer selling them, so I've been on a search for one or an equivalent. These are not.
There's no stuffing to get all over the place when your pup breaks into it, a plus. However the squeakers weren't particularly loud and were silenced in a few hours. Two were dead and the remaining one was very well on its way. The toy itself was pretty much intact but that had more to do with the lack of attention from the dog than how rugged the toy is. He'll pick it up once in a while but it certainly didn't meet my expectations.
The good thing is that there are three of them so I can give him some brief excitement in the future. Wouldn't buy again.
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Reviewed in the United States on February 24, 2023
★★★★★ 5
Strong Chewer Friendly Toy
Style: Variety Pack - Large (3-pack)
My dog is a rough chewer and these last a really long time (clearly since this beaver's face is long gone! The no stuffing is a win too for cleaning up afterwards.
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Reviewed in the United States on April 26, 2026
★★★★★ 5
Dog toy
Mammoth Flossy Chews 100 Percent Natural Cotton Rope Dog Toy is an absolute hit with my furry friend! The premium quality, natural cotton rope construction ensures durability and safety for hours of interactive play. The white knot design adds an extra element of fun and intrigue, perfect for tug-of-war sessions or solo chewing. Despite its sturdy build, it's gentle on my dog's teeth and gums. Plus, the mini 6" size is ideal for small dogs, providing them with a satisfying chewing experience. Overall, Mammoth Flossy Chews earns a solid 5-star rating for its quality, durability, and entertainment value for my pup!
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Reviewed in the United States on May 5, 2024