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Description
Alexa Fluor® 647 Mouse Anti-Human MICA Antibody (S-2794)Product Specification Host Mouse Antigen MICA Synonyms MHC class I polypeptide related sequence A; MIC A; PERB11. 1 Location Cytoplasm, Cell membrane, Endoplasmic reticulum Accession Q29983 Clone Number S 2794 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample HeLa Purification Protein G Concentration 0. 05mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer PBS, 25% Glycerol, 1% BSA, 0. 3%
Product Specification
| Host | Mouse |
| Antigen | MICA |
| Synonyms | MHC class I polypeptide-related sequence A; MIC-A; PERB11.1 |
| Location | Cytoplasm, Cell membrane, Endoplasmic reticulum |
| Accession | Q29983 |
| Clone Number | S-2794 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | HeLa |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
MICA (MHC class I polypeptide-related sequence A) is a critical immune regulatory protein belonging to the non-classical MHC class I family. Encoded by the MICA gene on human chromosome 6, it is typically expressed on epithelial cells, fibroblasts, and endothelial cells, with upregulated expression under stress conditions such as infection, heat shock, or malignant transformation. Structurally, MICA resembles classical MHC class I molecules, featuring α1, α2, and α3 extracellular domains, but unlike MHC I, it does not bind β2-microglobulin or present antigens. Its primary function involves interaction with the activating receptor NKG2D (Natural Killer Group 2 Member D) on NK cells and cytotoxic T cells, triggering cytotoxicity and cytokine production, thereby playing a key role in antitumor and antimicrobial immunity. Tumors often evade immune surveillance by proteolytic shedding of MICA, making it a significant target in cancer immunotherapy. MICA's high polymorphism (over 100 alleles) is also associated with autoimmune diseases and transplant rejection. Additionally, certain viruses (e.g., cytomegalovirus) encode proteins that disrupt MICA-NKG2D interactions to evade immune clearance.
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