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Description
LC3B Recombinant Rabbit mAb (S-1599-142)Product Specification Host Rabbit Antigen LC3B Synonyms Microtubule associated protein 1 light chain 3 beta; Autophagy related protein LC3 B; Autophagy related ubiquitin like modifier LC3 B; MAP1 light chain 3 like protein 2; Microtubule associated proteins 1A 1B light chain 3B (MAP1A MAP1B LC3 B; MAP1A MAP1B light chain 3 B); MAP1ALC3; MAP1LC3B Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton, Mitochondrion Accession Q9GZQ8 Clone Number S
Product Specification
| Host | Rabbit |
| Antigen | LC3B |
| Synonyms | Microtubule-associated protein 1 light chain 3 beta; Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; MAP1 light chain 3-like protein 2; Microtubule-associated proteins 1A/1B light chain 3B (MAP1A/MAP1B LC3 B; MAP1A/MAP1B light chain 3 B); MAP1ALC3; MAP1LC3B |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton, Mitochondrion |
| Accession | Q9GZQ8 |
| Clone Number | S-1599-142 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Bv |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:200-1:500 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
LC3B protein is a crucial component in the autophagy process. It is a member of the LC3/GABARAP family of proteins. During autophagy, LC3B is cleaved by the enzyme Atg4 to generate the cytosolic form LC3B - I. Then LC3B - I is conjugated to phosphatidylethanolamine to form the membrane - bound form LC3B - II, which is recruited to the autophagosome membrane and plays an important role in the formation and maturation of autophagosomes. The conversion of LC3B - I to LC3B - II is often used as a marker to monitor autophagy activity. LC3B is involved in various cellular processes including the clearance of damaged organelles and protein aggregates, maintaining cellular homeostasis and responding to cellular stress such as nutrient deprivation and hypoxia. Dysregulation of LC3B - related autophagy has been implicated in the pathogenesis of many diseases like neurodegenerative disorders and cancer.
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
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