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Description
S-RMab® MLH1 Recombinant Mouse mAb,PBS Only (SDT-R702)Product Specification Host Mouse Antigen MLH1 Synonyms DNA mismatch repair protein Mlh1; MutL protein homolog 1; COCA2 Immunogen Synthetic Peptide Location Nucleus Accession P40692 Clone Number SDT R702 Antibody Type Recombinant mAb Isotype IgG1, Application IHC P Reactivity Hu Purification Protein G Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12 months from date of receipt
Product Specification
| Host | Mouse |
| Antigen | MLH1 |
| Synonyms | DNA mismatch repair protein Mlh1; MutL protein homolog 1; COCA2 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P40692 |
| Clone Number | SDT-R702 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG1,κ |
| Application | IHC-P |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:100-1:250 | Hu |
Background
DNA mismatch repair protein Mlh1 or MutL protein homolog 1 is a protein that in humans is encoded by the MLH1 gene located on chromosome 3. It is a gene commonly associated with hereditary nonpolyposis colorectal cancer. MLH1 protein is one component of a system of seven DNA mismatch repair proteins that work coordinately in sequential steps to initiate repair of DNA mismatches in humans [PMID: 18543306]. Defects in mismatch repair, found in about 13% of colorectal cancers, are much more frequently due to deficiency of MLH1 than deficiencies of other DNA mismatch repair proteins [PMID: 15887099]. The seven DNA mismatch repair proteins in humans are MLH1, MLH3, MSH2, MSH3, MSH6, PMS1 and PMS2.
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