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Description
MUC18/CD146 His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms MCAM, CD146, MUC18 Accession A0A5F8A4A1 Amino Acid Sequence Val24Gly559, with C terminal His Expression System HEK293 Molecular Weight 75 100kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation.
Product Specification
| Species | Cynomolgus |
| Synonyms | MCAM, CD146, MUC18 |
| Accession | A0A5F8A4A1 |
| Amino Acid Sequence | Val24–Gly559, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 75-100kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Fritzsche F R. et al. (2008) CD146 protein in prostate cancer: revisited with two different antibodies. Pathology. 40(5): 457-464. 2、Bidlingmaier S. et al. (2009) Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma. Cancer Res. 69(4): 1570-1577. 3、Boneberg E M. et al. (2009) Soluble CD146 is generated by ectodomain shedding of membrane CD146 in a calcium-induced, matrix metalloprotease-dependent process. Microvasc Res. 78(3): 325-331. |
Background
CD146, also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. The stromal vascular fraction (SVF) isolated from adipose tissue has been shown to be beneficial for treating peripheral nerve injuries. Micronized cellular adipose matrix (MCAM) is a SVF-rich micronized fat tissue obtained by a series of simple mechanical processes. The aim of this study is to assess the therapeutic effect of MCAM for peripheral nerve injury. An ANC filled with MCAM was implanted into a sciatic nerve defect in immunodeficient mice. Comparisons of this treatment with an autograft, an ANC filled with SVF cells, and an ANC alone were made based on electrophysiologic characteristics, sciatic function index, histological analyses of regenerated nerve fiber and myelination using electron microscopy, and the preventive effect on innervated muscle atrophy. These effects were significantly improved than in the control group (ANC only) and comparable to those in the SVF group, whereas the improvement did not reach the same level of autograft group.Injection of MCAM into an ANC accelerated nerve regeneration compared with use of an ANC alone and this effect, which indicate that MCAM is a promising transplant material for treatment of peripheral nerve injury and an alternative to use of SVF cells.
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4.8 ★★★★★
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Product Reviews
★★★★★ 4
Breathable fabric
Color: Army Green, Size: X-Large
Breathable fabric, tighter fit than expected.
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Reviewed in the United States on May 14, 2026
★★★★★ 5
Great quality tank tops!
Color: Apricot, Size: Medium, Color: Apricot, Size: Medium
Had to take a quick minute to review these tank tops. Extremely soft, lightweight, comfortable, breathable, and sweat wicking & stretchy. Seem to conform and fit athletically without being too tight at all. I live in Phoenix and the summers are blistering, and this is probably one of the best tank tops I have owned. Athletic enough to wear to the gym or go for a run but stylish enough to just wear casually as a summer tank top as well. I ended up ordering two more for a total of three so far and likely will get yet another one in a different color. So far have kept their shape & color with laundry as well. Great job and amazing value!
(just for reference I’m about 6,1” and 160 lbs, athletically built but slender and ordered a medium and it’s perfect).
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Reviewed in the United States on June 28, 2025
★★★★★ 5
Flattering, Durable, and Worth Buying Twice
Color: Army Green, Size: Large
Love the material on these. I bought the green and loved it so much, I bought the black too. It's stretchy material and that is very durable. It's also flattering as it hugs the chest and shoulders, but is loose on the stomach if you have a bit of a gut. Great for showing off your arms. Washes great without shrinkage or fading. Looks higher quality than a cotton tank.
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Reviewed in the United States on March 10, 2026
★★★★★ 3
Could be better
Color: Black, Size: 3X-Large
It’s not bad. But!, I wish it was an inch longer. I got a 3x and idk why manufacturers always increase the neck hole on larger sizes. It’s a femininely large neck hole. I may send it back ? Not sure yet.
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Reviewed in the United States on May 7, 2026
★★★★★ 5
Stylish tank
Color: Apricot, Size: Medium
Comfort and stylish. Fit me perfectly 5’11” at 178 pounds
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Reviewed in the United States on April 30, 2026