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Description
ATP7B Recombinant Rabbit mAb (S-2827-58)Product Specification Host Rabbit Antigen ATP7B Synonyms Copper transporting ATPase 2; Copper pump 2; Wilson disease associated protein; PWD; WC1; WND Immunogen Recombinant Protein Location Cytoplasm, Endosome, Mitochondrion Accession P35670 Clone Number S 2827 58 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample HepG2, Caco 2, K562, HEK 293 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | ATP7B |
| Synonyms | Copper-transporting ATPase 2; Copper pump 2; Wilson disease-associated protein; PWD; WC1; WND |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Endosome, Mitochondrion |
| Accession | P35670 |
| Clone Number | S-2827-58 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | HepG2, Caco-2, K562, HEK-293 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
ATP7B is a P-type ATPase copper-transporting beta polypeptide that acts as the liver-specific efflux pump, using ATP hydrolysis to move cytosolic Cu⁺ across membranes into the trans-Golgi network for incorporation into ceruloplasmin or, when copper is elevated, to vesicles that fuse with the canalicular membrane to excrete excess copper into bile, thereby maintaining systemic copper homeostasis; mutations in ATP7B disable this export, causing toxic hepatic and brain copper accumulation that defines the autosomal-recessive disorder Wilson disease.
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