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Description
CD82 Recombinant Rabbit mAb (S-1777-170)Product Specification Host Rabbit Antigen CD82 Synonyms CD82 antigen; C33 antigen; IA4; Inducible membrane protein R2; Metastasis suppressor Kangai 1; Suppressor of tumorigenicity 6 protein; Tetraspanin 27 (Tspan 27); KAI1; SAR2; ST6; TSPAN27 Immunogen Synthetic Peptide Location Cell membrane Accession P27701 Clone Number S 1777 170 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms Positive Sample Caco 2, Ramos, Raji, Jurkat,
Product Specification
| Host | Rabbit |
| Antigen | CD82 |
| Synonyms | CD82 antigen; C33 antigen; IA4; Inducible membrane protein R2; Metastasis suppressor Kangai-1; Suppressor of tumorigenicity 6 protein; Tetraspanin-27 (Tspan-27); KAI1; SAR2; ST6; TSPAN27 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | P27701 |
| Clone Number | S-1777-170 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms |
| Positive Sample | Caco-2, Ramos, Raji, Jurkat, RAW264.7, mouse spleen |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Hu, Ms |
Background
CD82 protein, also known as KAI1, is a member of the tetraspanin family of proteins. It is a transmembrane glycoprotein that plays a significant role in various biological processes such as cell adhesion, migration, and apoptosis. CD82 is widely expressed in normal tissues and has been identified as a metastasis suppressor in many types of cancer. It can form complexes with integrins and other tetraspanins to regulate intercellular adhesion and signaling. For example, CD82 inhibits β-catenin tyrosine phosphorylation and stabilizes E-cadherin-β-catenin complexes at the cell membrane, which helps to limit cancer cell dissociation from the primary cancer nest and metastasis. Additionally, CD82 is also found to be expressed in human trophoblast cells and plays a role in inhibiting trophoblast invasion and migration during early pregnancy.
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