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Description
Human IL-17A OneStep ELISA KitProduct Specification Antigen IL 17A Immunogen Recombinant Protein Antibody Type Recombinant mAb Reactivity Hu Purification Protein A Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C as supplied. Kit Precision Intra assay: 4. 2% Inter assay: 8. 7% Sample type Cell culture supernatant, Serum,Plasma Assay type Sandwich (quantitative) Sensitivity 0. 880 pg ml Range 3. 9 pg mL 250 pg mL Recovery Cell culture supernatant: 99%
Product Specification
| Antigen | IL-17A |
| Immunogen | Recombinant Protein |
| Antibody Type | Recombinant mAb |
| Reactivity | Hu |
| Purification | Protein A |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Kit
| Precision | Intra-assay:4.2%； Inter-assay: 8.7% |
| Sample type | Cell culture supernatant, Serum,Plasma |
| Assay type | Sandwich (quantitative) |
| Sensitivity | 0.880 pg/ml |
| Range | 3.9 pg/mL – 250 pg/mL |
| Recovery | Cell culture supernatant: 99% Serum: 84% Plasma: 106% |
| Assay time | 60 minutes |
| Species reactivity | Human |
| NIBSC convert | The dose response curve of the International Standard (01/420) parallels the OneStep standard curve. To convert sample values obtained with the kit to approximate NIBSC (01/420) units, use the following equation: NIBSC (01/420) approximate value (IU/mL) = 0.01 x OneStep Human IL-17A value (pg/mL). |
Background
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.
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