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Description
BANK1 Recombinant Rabbit mAb (SDT-2265-37)Product Specification Host Rabbit Antigen BANK1 Synonyms B cell scaffold protein with ankyrin repeats Immunogen Recombinant Protein Location Cytoplasm Accession Q8NDB2 Clone Number SDT 2265 37 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample Daudi, mouse spleen Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%
Product Specification
| Host | Rabbit |
| Antigen | BANK1 |
| Synonyms | B-cell scaffold protein with ankyrin repeats |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm |
| Accession | Q8NDB2 |
| Clone Number | SDT-2265-37 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Daudi, mouse spleen |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| IHC-P | 1:100 | Hu, Ms, Rt |
Background
BANK1, or B cell scaffold protein with ankyrin repeats 1, is primarily expressed in B cells and plays multiple roles in B cell signaling pathways, including B cell receptor signaling, CD40-related signaling, and Toll-like receptor (TLR) signaling. The gene for BANK1 is located on chromosome 4q24 and contains genetic variants associated with autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis. The protein has three conserved domains: two double ankyrin repeat-like motifs, a coiled-coil domain, and a Dof/BCAP/BANK (DBB) motif. It can bind to Src family kinases like LYN and BLK, and interact with PLC-γ2 and TRAF6, modulating various signaling processes. Different isoforms of BANK1 exist, with the full-length isoform and the Δ2 isoform (lacking exon 2) having distinct roles in disease susceptibility.
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