Pay in installments of $25.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 12 - Aug 17
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
FITC Mouse Anti-Human CD148 Antibody (S-3121)Product Specification Host Mouse Antigen CD148 Synonyms Receptor type tyrosine protein phosphatase eta; Protein tyrosine phosphatase eta; R PTP eta; Density enhanced phosphatase 1 (DEP 1); HPTP eta; Protein tyrosine phosphatase receptor type J (R PTP J); DEP1; PTPRJ Location Cell membrane Accession Q12913 Clone Number S 3121 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample human peripheral blood Leukocytes
Product Specification
| Host | Mouse |
| Antigen | CD148 |
| Synonyms | Receptor-type tyrosine-protein phosphatase eta; Protein-tyrosine phosphatase eta; R-PTP-eta; Density-enhanced phosphatase 1 (DEP-1); HPTP eta; Protein-tyrosine phosphatase receptor type J (R-PTP-J); DEP1; PTPRJ |
| Location | Cell membrane |
| Accession | Q12913 |
| Clone Number | S-3121 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human peripheral blood Leukocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD148 (also called PTPRJ or DEP-1) is a ~220 kDa receptor-type protein tyrosine phosphatase of the R3 subfamily that contains an extracellular region with eight fibronectin III-like repeats, a single transmembrane segment, and an intracellular catalytic domain; it is broadly expressed in hematopoietic and non-hematopoietic cells where it functions as a key negative regulator of growth-factor and adhesion signaling by dephosphorylating receptor tyrosine kinases such as PDGFR, VEGFR, EGFR, and Eph receptors, thereby inhibiting downstream PI3K/AKT, MAPK, and Src-family kinase pathways, promoting contact-inhibited growth, stabilizing cadherin-mediated cell–cell junctions, and acting as a tumor suppressor whose loss or down-regulation is associated with enhanced proliferation, migration, and metastasis in cancers of the stomach, colon, lung, thyroid, and breast.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy