SKU: 58240844748

ALK Recombinant Rabbit mAb,PBS Only (SDT-3284)

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Description

ALK Recombinant Rabbit mAb,PBS Only (SDT-3284)Product Specification Host Rabbit Antigen ALK Synonyms ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; CD246 Location Cell membrane Accession Q9UM73 Clone Number SDT 3284 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample SH SY5Y, IMR 32 Purification Protein A Concentration 1mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12 months from date of

Product Specification


Host Rabbit
Antigen ALK
Synonyms ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; CD246
Location Cell membrane
Accession Q9UM73
Clone Number SDT-3284
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P
Reactivity Hu
Positive Sample SH-SY5Y, IMR-32
Purification Protein A
Concentration 1mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS

Stability & Storage

12 months from date of receipt / reconstitution, 4 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu
IHC-P 1:250 Hu

Background

Anaplastic lymphoma kinase (ALK), also designated CD246, is a single-pass transmembrane receptor tyrosine kinase of the insulin-receptor superfamily that is normally expressed at highest levels in the developing and adult nervous system, where it regulates neuronal differentiation, axon guidance and cognition; the 1620-aa glycoprotein presents an N-terminal extracellular region containing two MAM domains and an LDL-A module for ligand binding, a single hydrophobic transmembrane segment and a C-terminal cytoplasmic kinase domain that, upon ligand-induced dimerization, undergoes trans-autophosphorylation and triggers RAS–MAPK, PI3K–AKT and JAK–STAT signaling cascades controlling cell proliferation and survival. Chromosomal translocations (most famously t(2;5)(p23;q35) producing NPM1–ALK), inversions (EML4–ALK in non-small-cell lung cancer) or activating point mutations cause constitutive kinase activity, driving malignant transformation in anaplastic large-cell lymphoma, subsets of NSCLC, neuroblastoma and inflammatory myofibroblastoma, making the oncoprotein a validated therapeutic target for small-molecule inhibitors such as crizotinib, alectinib and lorlatinib.

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SKU: 58240844748

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MLA
Dallas, US
★★★★★ 4
Nice shirt for the price
Color: White, Size: Large
Good quality shirt, especially for the price. Drapes nicely, almost a painterly feel with the fabric. Works across the wardrobe spectrum, pairing well with slacks in a business setting or with chinos for a more casual look.
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Reviewed in the United States on April 29, 2026
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Shopper1234
Houston, US
★★★★★ 5
Comfortable
Color: Granite Gray, Size: X-Large
Great fit, quality.
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Reviewed in the United States on May 18, 2026
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james granata
New York, US
★★★★★ 3
Very unreliable size chart second and final time I go there.
Color: Angel Falls, Size: Medium
Size chart unreliable, medium very baggy, decent quality
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Reviewed in the United States on April 24, 2026
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Ron's Raves & Roasts
Carnegie, US
★★★★★ 5
Great Fit and Price While Updating My Wardrobe
Color: Shortbread, Size: Large
As I’ve been getting fitter, my old clothes started looking too baggy, so I needed something that fit better without breaking the bank. This COOFANDY chambray shirt turned out to be exactly what I was looking for—lightweight, wrinkle-resistant, and stylish enough for casual or dressy wear. The fabric feels soft and breathable, and it pairs easily with jeans or slacks. Since I’m still losing weight, I didn’t want to overspend on clothes I may size out of soon, and these hit the sweet spot for both quality and affordability.
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Reviewed in the United States on September 28, 2025
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Lyle Miller
New York, US
★★★★★ 1
Wron Size Shipped Twice
Color: White, Size: Large
I ordered a large twice. 1st delivery was an XL, two sizes too large. The second reorder was an L, and fit like a medium. They can't get the order siz right.
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Reviewed in the United States on May 7, 2026

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