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Description
FXR1 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen FXR1 Synonyms RNA binding protein FXR1; FMR1 autosomal homolog 1; hFXR1p Immunogen Synthetic Peptide Location Cytoplasm Accession P51114 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt, Mk Positive Sample MCF7, HEK 293, HeLa, HepG2, A549, C2C12, mouse liver, mouse skeletal muscle, rat liver, rat skeletal muscle Predicted Reactivity Bv, Hm Purification Immunogen
Product Specification
| Host | Rabbit |
| Antigen | FXR1 |
| Synonyms | RNA-binding protein FXR1; FMR1 autosomal homolog 1; hFXR1p |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | P51114 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | MCF7, HEK-293, HeLa, HepG2, A549, C2C12, mouse liver, mouse skeletal muscle, rat liver, rat skeletal muscle |
| Predicted Reactivity | Bv, Hm |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:1000 | Hu, Ms, Rt |
Background
FXR1 (Fragile X-related protein 1) is an evolutionarily conserved RNA-binding protein that contains three KH domains and an RGG box, enabling it to recognize and regulate the stability, splicing, subcellular transport and translation of a wide spectrum of mRNAs and miRNAs; it shuttles between nucleus and cytoplasm, acts as a cytoplasmic m⁶A reader, forms functional amyloid aggregates in neurons, controls muscle and vascular smooth-muscle cytoskeleton organization, blood pressure and inflammatory transcript decay, and is indispensable for early embryogenesis, placental trophoblast migration, neuronal miRNA processing and long-term memory, while its over-expression or amplification is linked to poor prognosis in multiple cancers.
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