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Description
AMPKβ1/2 Recombinant Rabbit mAb (S-2728-26)Product Specification Host Rabbit Antigen AMPK1 2 Synonyms 5' AMP activated protein kinase subunit beta 1 2; AMPK subunit beta 1 2; AMPKb; AMPK Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q9Y478O43741 Clone Number S 2728 26 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample HepG2, HeLa, A549, 293T, HEK 293, NIH 3T3, mouse brain, mouse liver, rat brain, COS 7 Predicted
Product Specification
| Host | Rabbit |
| Antigen | AMPKβ1/2 |
| Synonyms | 5'-AMP-activated protein kinase subunit beta-1/2; AMPK subunit beta-1/2; AMPKb; AMPK |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | Q9Y478、O43741 |
| Clone Number | S-2728-26 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HepG2, HeLa, A549, 293T, HEK-293, NIH/3T3, mouse brain, mouse liver, rat brain, COS-7 |
| Predicted Reactivity | Bv, Or |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:200 | Hu, Ms |
| ICC | 1:100 | Hu, Ms |
Background
AMPKβ1/2 are indispensable scaffolding isoforms of the 5′-AMP-activated protein kinase (AMPK) complex that harbor a conserved carbohydrate-binding module (CBM) which docks glycogen and related oligosaccharides to allosterically sensitize the holoenzyme to cellular energy stress, while simultaneously anchoring the α-catalytic and γ-regulatory subunits through their C-terminal sequences to ensure correct heterotrimeric assembly, stable lysosomal or mitochondrial localization, and optimal phosphorylation-mediated activation by upstream kinases such as LKB1 and CaMKK2, thereby governing systemic metabolic fluxes including fatty-acid oxidation, glucose uptake, and autophagy in liver, skeletal muscle, and adipose tissue.
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