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Description
Human CD43 Protein, His TagProduct Specification Species Human Synonyms Leukosialin, GPL115, Galactoglycoprotein (GALGP), Leukocyte sialoglycoprotein, Sialophorin, SPN Accession P16150 Amino Acid Sequence Protein sequence (P16150, Ser20 Arg253, with C His Tag)
Product Specification
| Species | Human |
| Synonyms | Leukosialin, GPL115, Galactoglycoprotein (GALGP), Leukocyte sialoglycoprotein, Sialophorin, SPN |
| Accession | P16150 |
| Amino Acid Sequence | Protein sequence (P16150, Ser20-Arg253, with C-His Tag) STTAVQTPTSGEPLVSTSEPLSSKMYTTSITSDPKADSTGDQTSALPPSTSINEGSPLWTSIGASTGSPLPEPTTYQEVSIKMSSVPQETPHATSHPAVPITANSLGSHTVTGGTITTNSPETSSRTSGAPVTTAASSLETSRGTSGPPLTMATVSLETSKGTSGPPVTMATDSLETSTGTTGPPVTMTTGSLEPSSGASGPQVSSVKLSTMMSPTTSTNASTVPFRNPDENSR |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 25.1 kDa Observed MW: 40-120 kDa |
| Purity | ＞90% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
Leukosialin also known as sialophorin or CD43 (cluster of differentiation 43) is a transmembrane cell surface protein. Sialophorin (leukosialin) is a major sialoglycoprotein on the surface of human T lymphocytes, monocytes, granulocytes, and some B lymphocytes, which appears to be important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation. Defects in the CD43 molecule are associated with the development of Wiskott–Aldrich syndrome. It also appears in about 25% of intestinal MALTomas. Using immunohistochemistry, CD43 can be demonstrated in the paracortical T-cells of healthy lymph nodes and tonsils; it is also positive in a range of lymphoid and myeloid tumours. Because it stains granulocytes and their precursors, it is an effective marker for myeloid tumours.
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