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Description
ADAM10 Rabbit polyclonal antibodyProduct Specification Host Rabbit Synonyms Disintegrin and metalloproteinase domain containing protein 10, CDw156, Kuzbanian protein homolog, Mammalian disintegrin metalloprotease, CD156c Immunogen Synthetic Peptide Location Cell membrane Accession O14672 Antibody Type Polyclonal antibody Isotype IgG Application WB, ICC, ICFCM, IP Reactivity Hu, Ms Predicted Reactivity Rt, Pg, Bv Purification Immunogen Affinity Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Synonyms | Disintegrin and metalloproteinase domain-containing protein 10, CDw156, Kuzbanian protein homolog, Mammalian disintegrin-metalloprotease, CD156c |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | O14672 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, ICC, ICFCM, IP |
| Reactivity | Hu, Ms |
| Predicted Reactivity | Rt, Pg, Bv |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IP | 1:50 | |
| ICC | 1:500 | |
| ICFCM | 1:50 |
Background
ADAM10 is a sheddase, and has a broad specificity for peptide hydrolysis reactions. ADAM10 cleaves ephrin, within the ephrin/eph complex, formed between two cell surfaces. When ephrin is freed from the opposing cell, the entire ephrin/eph complex is endocytosed. In neurons, ADAM10 is the most important enzyme, with α-secretase activity for proteolytic processing of the amyloid precursor protein. ADAM10, along with ADAM17, cleaves the ectodomain of the triggering receptor expressed on myeloid cells 2 (TREM2), to produce soluble TREM2 (sTREM2), which has been proposed as a CSF and sera biomarker of neurodegeneration. ADAM10 being a major determinant of HER2 shedding, the inhibition of which, may provide a novel therapeutic approach for treating breast cancer and a variety of other cancers with active HER2 signaling.
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