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Description
FITC Rat Anti-Mouse/Human CD45R/B220 Antibody (S-R519)Product Specification Host Rat Antigen CD45R B220 Synonyms Receptor type tyrosine protein phosphatase C; Leukocyte common antigen (L CA); Lymphocyte antigen 5 (Ly 5); T200; Ptprc; Ly 5 Location Cell membrane Accession P06800 Clone Number S R519 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Hu, Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 0. 05mg ml Conjugation FITC Physical Appearance Liquid
Product Specification
| Host | Rat |
| Antigen | CD45R/B220 |
| Synonyms | Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen (L-CA); Lymphocyte antigen 5 (Ly-5); T200; Ptprc; Ly-5 |
| Location | Cell membrane |
| Accession | P06800 |
| Clone Number | S-R519 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Hu, Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu, Ms |
Background
CD45R, also known as B220, is a protein tyrosine phosphatase that is predominantly found on B cells, at varying levels from pro-B cells to activated B cells, and may also be detected on certain T cell and NK cell subsets. CD45R plays a crucial role in B cell receptor and T cell receptor signaling and is essential for lymphocyte development and function. It helps regulate the threshold of sensitivity to external stimuli, affecting cellular responses. In mice, CD45R/B220 is a common marker for B cells, whereas in humans, B cells do not express B220 in the same way; it appears to be differentiation-specific and is therefore expressed on only some B cell subsets. CD45R is also used in the classification of leukemias and lymphomas and in research on functional subsets of B and T cells.
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