SKU: 64295104038

IFN-alpha/beta R1 His Tag Protein, Human

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Description

IFN-alpha/beta R1 His Tag Protein, HumanProduct Specification Species Human Synonyms IFNAR1,IFNAR,CRF2 1,IFN R 1,IFNAR 1,IFNBR Accession P17181 1 Amino Acid Sequence Lys28 Lys436 with His Tag at the C Terminus Expression System HEK293 Molecular Weight 70 95kDa (Reducing) Purity 95% by SDS PAGE & > 95% by SEC HPLC Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the

Product Specification


Species Human
Synonyms IFNAR1,IFNAR,CRF2-1,IFN-R-1,IFNAR-1,IFNBR
Accession P17181-1
Amino Acid Sequence

Lys28-Lys436 with His Tag at the C-Terminus

Expression System HEK293
Molecular Weight 70-95kDa (Reducing)
Purity >95% by SDS-PAGE & > 95% by SEC-HPLC
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized powder
Storage Buffer

PBS, PH7.4, 5% trehalose

Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.

Reference

1.Groen K, Kuratli R, Enkelmann J, Fernbach S, Wendel-Garcia PD, Staiger WI, Lejeune M, Sauras-Colón E, Roche-Campo F, Filippidis P, Rauch A; Swiss HIV Cohort Study; Trkola A, Günthard HF, Kouyos RD, Brugger SD, Hale BG. Type I interferon autoantibody footprints reveal neutralizing mechanisms and allow inhibitory decoy design. J Exp Med. 2025 Jun 2;222(6):e20242039.
2.Amendolara R, D'Onofrio L, Sessa RL, Di Giulio S, Mignogna C, Coraggio L, Schirano R, Zampetti S, Malandrucco I, Pozzilli P, Giannini G, Maddaloni E, Buzzetti R. IFN-α Neutralizing Antibodies Distinguish LADA From Early-onset Type 1 Diabetes. J Clin Endocrinol Metab.
3.Abramovich C,et al.(1997) A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor. EMBO J. 16(2): 260-6.

Background

Interferon α/β receptor 1 (IFNAR1) is a key component of the type I interferon (IFN-α/β) receptor. It belongs to the type II cytokine receptor family and is a type I transmembrane protein. Its extracellular region contains four fibronectin type III domains. IFNAR1 must form a functional receptor complex with another subunit, IFNAR2, to mediate type I interferon signal transduction. Upon ligand binding, the receptor activates downstream JAK kinases (such as Tyk2), which in turn phosphorylate transcription factors such as STAT1 and STAT2, initiating the expression of antiviral and immunomodulatory genes. Research suggests that its signaling mechanisms are complex: on the one hand, under specific conditions (such as during IFN-β signaling), IFNAR1 can function independently without relying on IFNAR2, and this pathway may not involve the classical JAK-STAT pathway; on the other hand, Tyk2 can stabilize IFNAR1 expression by inhibiting its endocytosis, while mutations at key tyrosine sites (e.g., Tyr466) can block STAT phosphorylation in a dominant-negative manner, confirming the central role of IFNAR1 in linking JAK and STAT. IFNAR1 itself also possesses direct antiviral activity.As the gateway for type I interferon signaling, IFNAR1 is a critical target in antiviral immunity, autoimmune diseases, and tumor immunotherapy. Hyperactivation or abnormal signaling of the receptor is associated with autoimmune diseases (such as systemic lupus erythematosus), while functional defects may increase susceptibility to viral infections. Modulation of this receptor and its signaling pathway provides important directions for the development of antiviral drugs, therapies for autoimmune diseases, and novel immune adjuvants.

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SKU: 64295104038

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Shawna
San Leandro, US
★★★★★ 3
Silicone socks
Size: M (up to size 9)-Beige
The socks are sized large. The quality of the silicone is good. But they slide around on your feet if you try to walk, making them difficult to use and a bit uncomfortable. Unless you are able to sit for long periods of time the likely will not work well. Recommend looking for a better value.
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Reviewed in the United States on October 27, 2024
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Ann
Fort Morgan, US
★★★★★ 5
Effective
Size: L (up to size 11)-Pink
Fantastic. I put lotion on my feet & wear them when I go to sleep. I often wake up during the night and will remove them to find my feet soft and smooth. They are strong and fit my size 10 womens’ size.
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Reviewed in the United States on March 27, 2026
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Stacy
Cuba, US
★★★★★ 1
The shoe size should be smaller 9 is the max and it is still to tight
Size: M (up to size 9)-Beige, Size: M (up to size 9)-Beige
Very tight had to take off my feet in the middle of the night they were cutting off my circulation.
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Reviewed in the United States on February 17, 2026
M
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michele p.
Dallas, US
★★★★★ 5
Great product to keep moisture in
Size: M (up to size 9)-Beige
These are so cool. I was skeptical at first. After an at home pedicure I put lotion on and keep these on for about a few hours. The moisture retention, and comfort and fit or absolutely amazing!
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Reviewed in the United States on April 24, 2025
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Amy
Charlottesville, US
★★★★★ 5
These work!
Size: M (up to size 9)-Beige
I’ve had dry cracked feet my whole life. Tried these last night with lotion from Trader Joe’s and literally overnight my feet are the softest they’ve ever been. I put a pair of socks over them and went to sleep with them on. Hard to walk around with all that slippery-ness but worth it! 10/10✨👌
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Reviewed in the United States on June 11, 2025

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