SKU: 64437121335

Rat Anti-Mouse CD3ε Antibody (S-3759)

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Description

Rat Anti-Mouse CD3ε Antibody (S-3759)Product Specification Host Rat Antigen CD3 Synonyms T cell surface glycoprotein CD3 epsilon chain; T cell surface antigen T3 Leu 4 epsilon chain; Cd3e Location Cell membrane Accession P22646 Clone Number S 3759 Antibody Type Rat mAb Isotype IgG2a Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability &

Product Specification


Host Rat
Antigen CD3ε
Synonyms T-cell surface glycoprotein CD3 epsilon chain; T-cell surface antigen T3/Leu-4 epsilon chain; Cd3e
Location Cell membrane
Accession P22646
Clone Number S-3759
Antibody Type Rat mAb
Isotype IgG2a
Application FCM
Reactivity Ms
Positive Sample C57BL/6 mouse splenocytes
Purification Protein G
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1:200 Ms

Background

CD3ε protein, also known as CD3E, is a crucial component of the T-cell receptor (TCR) complex, which is essential for T-cell activation and function. It is a single-pass type I membrane glycoprotein that contains one Ig-like domain and one immunoreceptor tyrosine-based activation motif (ITAM) domain. CD3ε, along with CD3γ, CD3δ, and CD3ζ, forms the TCR-CD3 complex, which plays a vital role in coupling antigen recognition to intracellular signal-transduction pathways. This protein is essential for the proper development of T-cells and is involved in the internalization and downregulation of the TCR-CD3 complex on the cell surface. Defects in the CD3ε gene can lead to severe immunodeficiency and have been linked to a susceptibility to type I diabetes in women.

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SKU: 64437121335

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4.8 ★★★★★
Based on 24 reviews
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A
Verified Purchase
Amazon Customer
Carnegie, US
★★★★★ 5
What a Ride!
Format: Kindle
I thoroughly enjoyed this book! I was intrigued by the blurb, "Mississippi Delta," "haunted by her great grandmother's nanny," and the book was even better than I expected. I laughed out loud, shook my head at the accuracy of the descriptions of Southern culture, and even stopped from time to time to admire sentence structure and vocabulary choices. A satisfying read. I would recommend this book to anyone who enjoys unraveling a mystery with an unsuspecting hero.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 2, 2024
T
Verified Purchase
Toni Davis
Charlottesville, US
★★★★★ 4
Another Good One
Format: Mass Market Paperback
Another good one in this series of stories.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 21, 2025
S
Verified Purchase
Sigrun Hardardottir
Charlottesville, US
★★★★★ 5
Great plots, lovely use of English, lovable characters.
Format: Kindle
This series is a joy to read for lovers of the English language. The characters are interesting and/lovable. My family on my mother’s side lives in Florida and growing up I was certainly subjected to the mores and traditional thinking of the South, which did not help me at all in life, so the exposure to that culture raises an exasperated smile in me. For someone like me who loves to read the fact that the books are longer than normal for cozy books makes me very happy.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 31, 2019
M
Verified Purchase
M. C. Crammer
Los Angeles, US
★★★★★ 5
This would be a terrific book even without the mystery!
Format: Mass Market Paperback
The book has so much literary merit, that it could be placed among the novels. However, the excellent mystery plot also wins it a place among the mysteries. Haines creates characters who are memorable and vivid and places them in the Mississippi Delta town of Zinnia (I'm kind of reminded of the movie "In the Heat of the Night"). Sarah Booth is living in the ancestral home -- she is an orphan and an only child, the last of the Delaneys -- but is about to lose it, because she is destitute despite her social credentials. Her only company at Dahlia House - the antebellum house -- is the ghost of a slave, who appears in a variety of outfits and "encourages" Sarah to get to work reproducing. In an attempt to earn some money, Sarah takes on the task of trying to get to the truth of a scandal from 20 years ago in which first a leading citizen and then the leading citizen's wife die in some very questionable accidents. THe two young offspring are whispered to have something to do with it, and Sarah's client wants to find out if Hamilton the Fifth is as bad as rumors have it. Hamilton the Fifth is a romantic interest worthy of Evanovich -- and did I mention the book is often funny? Sarah is stirring up some dangerous memories and some deaths start to follow. I really loved this book and can hardly wait to read the next in this series and discover what happens to Sarah.
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Reviewed in the United States on April 19, 2004
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Jenny Schwartz
Port Orchard, US
★★★★★ 3
Southern Melancholy
Format: Kindle
On the plus side, "Them Bones" delivered on transporting me to the Mississippi delta (how do you stop typing Mississippi? it just begs to go on endlessly, like banana). I was there in the South and in a small country town. Brilliant on setting, which is what I like in a cosy mystery. The mystery itself took a while to settle in and then, well, I guessed the plot. That meant instead of suspense, I plodded through having my hunches confirmed. But if I'd been charmed, that wouldn't have mattered. This is not a negative review, but I'm heading towards the big problem I had with the book -- and I think this may be related to the fact that I was so busy and looking to enjoy some simply, happy downtime. "Them Bones" has humour and a southern feel, but it also struck me as melancholic. And melancholy I did not need. For others (and maybe for me at a different time) that sense of mourning and tangled history might resonate. But it was a heavy load for the plot to carry. Three stars for a solid read.
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Reviewed in the United States on July 24, 2015

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