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Description
MARCKS Recombinant Rabbit mAb (S-3190-72)Product Specification Host Rabbit Antigen MARCKS Synonyms Myristoylated alanine rich C kinase substrate; Protein kinase C substrate; 80 kDa protein; light chain (80K L protein; PKCSL); MACS; PRKCSL Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton, Cell membrane Accession P29966 Clone Number S 3190 72 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu Positive Sample A431, HEK 293 Purification Protein A
Product Specification
| Host | Rabbit |
| Antigen | MARCKS |
| Synonyms | Myristoylated alanine-rich C-kinase substrate; Protein kinase C substrate; 80 kDa protein; light chain (80K-L protein; PKCSL); MACS; PRKCSL |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton, Cell membrane |
| Accession | P29966 |
| Clone Number | S-3190-72 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu |
| Positive Sample | A431, HEK-293 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:500 | Hu |
| ICC | 1:500 | Hu |
Background
MARCKS (Myristoylated Alanine-Rich C Kinase Substrate) is an evolutionarily conserved, intrinsically disordered peripheral membrane protein that serves as a key phosphorylation substrate for conventional and novel protein kinase C isoforms; by reversibly sequestering phosphatidylinositol-4,5-bisphosphate (PIP2) and cross-linking actin filaments, it integrates PKC, Ca2+/calmodulin, and small GTPase signaling to orchestrate dynamic membrane-cytoskeleton remodeling underlying cell adhesion, migration, endo/exocytosis, neurotransmitter release, and stem-cell differentiation, while its dysregulation contributes to cancer metastasis, inflammatory diseases, and neuronal disorders.
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