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Description
Biotinylated Fc γ RI/CD64 His&Avi Tag Protein, MouseProduct Specification Species Mouse Synonyms FCGR1A,FCG1,FCGR1,IGFR1,CD64,CD64A,FCRI Accession P26151 Amino Acid Sequence Glu25 Pro297, with C terminal His+Avi tag Expression System HEK293 Molecular Weight 43 53kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <1EU g Conjugation Unconjugated Tag Avi Tag, His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in
Product Specification
| Species | Mouse |
| Synonyms | FCGR1A,FCG1,FCGR1,IGFR1,CD64,CD64A,FCRI |
| Accession | P26151 |
| Amino Acid Sequence | Glu25-Pro297, with C-terminal His+Avi tag |
| Expression System | HEK293 |
| Molecular Weight | 43-53kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | Avi Tag, His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Joan Cid, Reyes Aguinaco, Rafael Sánchez, Graciano García-Pardo, Andreu Llorente: Neutrophil CD64 expression as marker of bacterial infection: A systematic review and meta-analysis. Journal of Infection, Volume 60, Issue 5, May 2010, Pages 313-319. |
Background
Fc γ RI, also known as CD64, is an integral cell membrane glycoprotein that transmits activation signals through the associated Fc R γ chain, commonly referred to as Fc-γ receptor 1 (Fc γ RI), and the high affinity recognition of IgG by Fc γ RI allows it to trigger effector responses at lower low IgG concentrations in early immune responses. After binding to IgG, CD64 interacts with an accessory chain called the common gamma chain, which has an ITAM motif necessary for triggering the cell and for activation. It is usually constitutively expressed on monocytes and macrophages, and can be induced by neutrophils and eosinophils, where its expression is upregulated in bacterial infections and sepsis.
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