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Description
PDK1/PDPK1 Recombinant Rabbit mAb (S-3050-116)Product Specification Host Rabbit Antigen PDK1 PDPK1 Synonyms 3 phosphoinositide dependent protein kinase 1; hPDK1 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus, Cell membrane Accession O15530 Clone Number S 3050 116 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Ms, Rt Positive Sample HEK 293, Jurkat, HeLa, K562, MCF7, 22Rv1, NIH 3T3, mouse testis, PC 12, rat testis Purification Protein A Concentration 0. 5 mg
Product Specification
| Host | Rabbit |
| Antigen | PDK1/PDPK1 |
| Synonyms | 3-phosphoinositide-dependent protein kinase 1; hPDK1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus, Cell membrane |
| Accession | O15530 |
| Clone Number | S-3050-116 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HEK-293, Jurkat, HeLa, K562, MCF7, 22Rv1, NIH/3T3, mouse testis, PC-12, rat testis |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
PDK1 (officially PDPK1), the 3-phosphoinositide-dependent protein kinase-1, is a 556-aa serine/threonine kinase whose N-terminal catalytic domain followed by a C-terminal PH domain that binds PtdIns(3,4,5)P3 and PtdIns(3,4)P2 generated by PI3K; once recruited to the plasma membrane it uses a docking-site motif (termed PIF-pocket) to phosphorylate the T-loop of AGC kinases such as AKT, S6K, SGK and PKC isoforms, thereby serving as the master upstream activator of the PI3K–AKT–mTOR signaling axis that controls cell growth, proliferation, survival and metabolism, while its dysregulation through PTEN loss, PI3K mutation or PDK1 overexpression is a frequent driver of cancer and metabolic disorders.
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