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Description
Anti-CD254 Monoclonal Antibody(Denosumab)Product Specification Host Human Synonyms Tumor necrosis factor ligand superfamily member 11, Osteoclast differentiation factor (ODF), Osteoprotegerin ligand, Receptor activator of nuclear factor kappa B ligand, TNF related activation induced cytokine, TNFSF11, OPGL, CD254, TRANCE Accession O14788 Clone Number S SC009 Antibody Type Recombinant mAb Isotype IgG1,k Application Blocking of RANKL signaling Functional assays Purification Protein A
Product Specification
| Host | Human |
| Synonyms | Tumor necrosis factor ligand superfamily member 11, Osteoclast differentiation factor (ODF), Osteoprotegerin ligand, Receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine, TNFSF11, OPGL, CD254, TRANCE |
| Accession | O14788 |
| Clone Number | S-SC009 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG1,k |
| Application | Blocking of RANKL signaling Functional assays |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Background
Denosumab is a human monoclonal antibody against RANKL used for the treatment of osteoporosis, treatment-induced bone loss, metastases to bone, and giant cell tumor of bone.
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4.4 ★★★★★
Based on 234 reviews
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Product Reviews
★★★★★ 5
Not all great stereo systems meet all the requirements for connectivity.
I want to go on record, the Onkyo TX-Nr7100 is an awesome choice for a stereo avr. Great connectivity, a warm sound quality, and many options for your audio sound choices. But, because it's base connectivity, as it applies to Bluetooth, I do not recommend to connecting a PC to it. Due to audio and video, data separation. The Onkyo, though an excellent stereo choice, has problems playing Youtube and other types of media, with built in audio and video playback. It defaults to the miniplayer, built into the system and is impossible to get rid of in these situations. I give this product 5 stars on quality and performance, but it was not made to connect to a computer. Stll, I recommend this AVR Stereo Receiver on its aesthetic look, sound, audio and connections and quality. Very important to keep this in mind for Computer and gaming console connection to this system.
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Reviewed in the United States on April 15, 2026
★★★★★ 5
Exceptional Home Theater Receiver with HDMI 2.1, Dirac Live & THX – Incredible Value
After researching extensively and using the TX‑NR7100 firsthand with a 5.1.4 Dolby Atmos setup, I’m thoroughly impressed by its blend of features, performance, and value.
Setup & Interface
The guided setup process is smooth and intuitive—Wi‑Fi setup, firmware updates, speaker configuration and HDMI mapping all work seamlessly. The on-screen menus are clean and accessible, though some deeper options may require a bit of navigation
With six HDMI 2.1 inputs and two HDMI 2.1 outputs, this receiver supports 8K/60Hz and 4K/120Hz video formats, along with VRR, eARC, and ALLM. This makes it ideal for gaming consoles like PS5 and Xbox Series X—performance is solid with no reported signal dropouts on the primary HDMI ports.
Audio & Sound Quality
Every channel delivers up to ~100 W into 8 Ω, powering immersive content such as Dolby Atmos and DTS:X with clarity and presence. THX post-processing adds dimension and scale, especially with cinematic soundtracks. Dirac Live room correction provides musical staging, precise imaging, cleaner dialog, and deeper bass—transformative for untreated or irregular rooms.
Streaming & Multi-Room
Equipped with AirPlay 2, Chromecast, Bluetooth (including aptX), and Sonos/DTS Play-Fi integration, streaming is flexible and robust. Spotify, Tidal, Pandora, TuneIn, and more are all supported. It even functions as a Roon endpoint with no signal issues when streaming high-res audio over Ethernet.
Build & Design
The front panel features a large green display, a straightforward volume dial, and basic controls. While the remote is functional, it isn’t backlit. The control app is usable but somewhat basic, making desktop Dirac calibration a better option for fine-tuning.
Pros:
Cutting-edge HDMI 2.1 support for 8K/60Hz, 4K/120Hz, VRR & eARC
THX Certified with immersive Atmos/DTS:X and IMAX Enhanced support
Powerful and convincing Dirac Live room correction
Versatile streaming ecosystem and smart assistant compatibility
Excellent price-to-performance ratio compared to peers
Cons:
HDMI glitches possible; best addressed via firmware updates and proper setup
Remote is not backlit; app UI is basic
Not truly expandable to 11-channel systems; no independent sub outs or extra preamp channels
Verdict:
The Onkyo TX‑NR7100 strikes a remarkable balance between modern video support, superior immersive audio, and intuitive usability—all at a price point that undercuts many similarly spec’d competitors. If you want future‑proof HDMI features, strong gaming performance, Dirac‑based room tuning, and multi‑room streaming options, this AVR delivers beyond expectation. Highly recommended.
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Reviewed in the United States on July 30, 2025
★★★★★ 5
Best deal and beautiful sound
I bought this one on sale to replace my old Pioneer VSX-1120-K 7.2 ch receiver which did not support 4K video and new Atmos sound profile. I would say, it was the best deal in this category since it offered 100 watts/ch , 9.2 ch, 8k/4k supported, and nearly 50% price cut when on sale! The sound quality is amazing, especially after using Dirac live to measure and auto adjust all speakers’ sound curves, making my home theater sound in a different level. The high is very clear but not harsh while the low is soft and nice punch. I also like the Onkyo App which helps to control the receiver in many ways. I can use it together with other online music streaming services app without touching the remote controller any more, very convenient! The only a small problem it has, is that it’s BD/DVD HDMI input sometimes does not work well with Amazon fire stick. It makes the firestick restart over again and again, so I have to use the other input such as game input to work smoothly with the firestick.
Update: I have had this receiver for more than a year now. I would say, I love it more and more! It not only supports 4K/8k video through HDMI, but also has so many listening sound models to choose from, and the App on smartphone is a very convenient tool. One of my favorite functions of it is the Dirac live function. I used to analyze the sound characteristics of each speaker, and fine tune the frequencies on them, making my home theater speakers up to a very high level, making every single sound frequency is in its best condition. This certainly compensates the shortcomings of certain sound frequencies in each speaker. Many times I just sat in my home theater listening to the music from Spotify without watching movie, and it was so joyful. I am changing the rate from 4 stars to five!
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Reviewed in the United States on March 26, 2024
★★★★★ 4
The basic set-up is relatively easy which was a big plus for me......
First let me start off by saying that I am not an audiophile. So, this review will not get into the weeds of the more complex settings this receiver is capable of. For example, the Dirac room measuring option. No way was I attempting to mess with that. Especially, after reading that some reviewers who actually have experience with Dirac found it could be confusing/difficult to set up. Besides I come from a previous Onkyo the TX-SR607 which had the AccuEQ Room Calibration similar to this receiver, so I used that instead with no issues. As far as hooking up the speakers it's pretty straight forward. If you have banana plugs, use them, seriously. I originally planned on using banana plugs but in order to save time I decided against that. But I wish I had taken the extra time to go with bananas because trying to thread the speaker wire into the speaker terminals is tedious, there not much room between the terminals and even me with my skinny fingers struggled a bit. Wish Onkyo designed their terminals side by side, but I think only Denon does that. Anyway, after all the speakers were connected (I'm currently using a 5.1.2 setup) and I connected my tv, Blu-ray player, CD player, etc., etc., I ran the AccuEQ Room Calibration, and I was good to go. I did change the some of the settings like speaker volume that AccuEQ has set but nothing major. I have noticed that I need to turn the volume up much higher on this Onkyo than on my previous one. What I mean by that is that on my previous Onkyo I would set the volume indicator at around 30-35 tops for movies. With this one it's more like 40-45, maybe how the volume is measured is different on this one. The sound is excellent for movies and music I have no complaints there. I have only tried a few of features so far like Airplay but will dig deeper into the manual (I downloaded from the internet) as time goes by. I will say as far as build quality is concerned it's not bad, but IMO my old Onkyo, a 2009 model, had the look and feel of a more expensive receiver. But it's what's inside that matters most so hopefully this one last as long as my previous Onkyo.
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Reviewed in the United States on February 22, 2024
★★★★★ 1
Sound unexpectantly blasted for no reason. It malfunctioned!
I spent hours between installation and set up! I had to return it. I turned on NET (network) to play Sirius Xm and the volume was low but after a few minutes the sound turned all the way up to maximum completely on its own? This happened at least two more times. I contacted ONKYO and was told it is clearly defective and that their is no solution to correct the problem, and that I should return it immediately! I purchased the newer model and am pleased with its performance! It’s unfortunate because the first one that had the issue with the sound really played nice, but having sound change its volume so suddenly to its full capacity was not what I expected, nor felt comfortable enough to keep as I said I was told to return it, which I did! My advice here would be to purchase the newer model, which seems to be much more stable in its performance, and the quality is excellent.
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Reviewed in the United States on November 29, 2025