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Description
AGTR1 Recombinant Rabbit mAb (S-2447-22)Product Specification Host Rabbit Antigen AGTR1 Synonyms Type 1 angiotensin II receptor; AT1AR; AT1BR; Angiotensin II type 1 receptor (AT1 receptor); AGTR1A; AGTR1B; AT2R1; AT2R1B Immunogen Synthetic Peptide Location Cell membrane Accession P30556 Clone Number S 2447 22 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample HEK 293, HepG2, HeLa, HT 1080, C2C12, PC 12, COS 7 Predicted Reactivity
Product Specification
| Host | Rabbit |
| Antigen | AGTR1 |
| Synonyms | Type-1 angiotensin II receptor; AT1AR; AT1BR; Angiotensin II type-1 receptor (AT1 receptor); AGTR1A; AGTR1B; AT2R1; AT2R1B |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | P30556 |
| Clone Number | S-2447-22 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HEK-293, HepG2, HeLa, HT-1080, C2C12, PC-12, COS-7 |
| Predicted Reactivity | Bv, Cz, Sh, GP, Dg, Rb |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:50-1:200 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
Background
AGTR1, the angiotensin II type 1 receptor, is a seven-transmembrane G-protein-coupled receptor that serves as the principal transducer of angiotensin II signaling in the renin–angiotensin–aldosterone system, mediating potent vasoconstriction, aldosterone and vasopressin release, renal sodium and water reabsorption, vascular smooth-muscle and cardiac hypertrophy, oxidative stress generation and sympathetic activation, thereby critically regulating systemic blood pressure and cardiovascular homeostasis; the receptor is widely expressed in kidney, heart, vasculature, adrenal gland and lung, can be activated not only by ligand binding but also by mechanical stretch, is transcriptionally up-regulated by inflammatory cytokines, undergoes endocytosis and heterodimerization that fine-tune its signaling output, and its chronic overactivity drives hypertension, cardiac and renal fibrosis, atherosclerosis and diabetic complications, while genetic polymorphisms that increase its expression or alter its regulation are linked to salt-sensitive hypertension and heightened cardiovascular risk .
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