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Description
MYO7A Recombinant Rabbit mAb (S-2284-21)Product Specification Host Rabbit Antigen MYO7A Synonyms Unconventional myosin VIIa; USH1B Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton, Synapse Accession Q13402 Clone Number S 2284 21 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, IF Reactivity Hu, Ms, Rt Positive Sample mouse testis, rat testis Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40%
Product Specification
| Host | Rabbit |
| Antigen | MYO7A |
| Synonyms | Unconventional myosin-VIIa; USH1B |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton, Synapse |
| Accession | Q13402 |
| Clone Number | S-2284-21 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, IF |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | mouse testis, rat testis |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500-1:1000 | Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| IF | 1:500 | Hu |
Background
MYO7A, encoded by the MYO7A gene, is an unconventional, actin-based molecular motor protein expressed in the inner ear and retina, where it is essential for the development and maintenance of stereocilia in cochlear and vestibular hair cells (critical for mechanotransduction and balance) and for melanosome transport within retinal pigment epithelium (RPE) cells (supporting retinal function). This large protein comprises an N-terminal motor domain, a lever arm with IQ motifs, and a C-terminal tail with MyTH4-FERM domains and an SH3 domain, enabling cargo binding and dimerization to generate processive movement along actin tracks. Mutations in MYO7A cause Usher syndrome type 1B (USH1B), leading to congenital deafness, vestibular dysfunction, and progressive retinitis pigmentosa, as well as nonsyndromic hearing loss (DFNA11 and DFNB2).
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