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Description
Human IL-8/CXCL8 HS OneStep ELISA KitProduct Specification Antigen lL 8 CXCL8 Immunogen Recombinant Protein Antibody Type Recombinant mAb Reactivity Hu Purification Protein A Stability & Storage 12 months from date of receipt reconstitution, 2 to 8'C as supplied. Kit Precision Intra assay: 2. 1% Inter assay: 3. 1% Sample type Cell culture supernatant; Serum; Plasma Assay type Sandwich (quantitative) Sensitivity 0. 459 pg mL Range 1. 71 pg mL 75 pg mL Recovery Cell culture supernatant:
Product Specification
| Antigen | lL-8/CXCL8 |
| Immunogen | Recombinant Protein |
| Antibody Type | Recombinant mAb |
| Reactivity | Hu |
| Purification | Protein A |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8'C as supplied. |
Kit
| Precision | Intra-assay: 2.1%； Inter-assay: 3.1% |
| Sample type | Cell culture supernatant; Serum; Plasma |
| Assay type | Sandwich (quantitative) |
| Sensitivity | 0.459 pg/mL |
| Range | 1.71 pg/mL – 75 pg/mL |
| Recovery | Cell culture supernatant: 109% Serum: 84% Plasma: 106% |
| Assay time | 60 minutes |
| Species reactivity | Hu |
Background
Human interleukin-8 (IL-8), also known as CXCL8, is a key CXC chemokine that functions as a central mediator of the inflammatory response. It is primarily produced by immune cells (such as macrophages) and tissue cells (like epithelial and endothelial cells) upon stimulation by infection or injury. IL-8’s most prominent role is as a potent chemoattractant and activator for neutrophils, guiding these white blood cells from the bloodstream to inflamed tissues by binding to its receptors, CXCR1 and CXCR2. Beyond recruiting neutrophils, IL-8 also promotes angiogenesis and enhances neutrophil antimicrobial functions. While essential for effective host defense, dysregulated or excessive IL-8 production is closely associated with the pathogenesis of numerous inflammatory diseases—including chronic obstructive pulmonary disease, rheumatoid arthritis, and inflammatory bowel disease—and contributes to tumor progression and metastasis in cancer, making it a significant biomarker and potential therapeutic target.
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Exchange/Return Notes
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