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Description
Alexa Fluor® 647 Mouse Anti-Human CD279 (PD-1) Antibody (S-R570)Product Specification Host Mouse Antigen CD279 (PD 1) Synonyms Programmed cell death protein 1; Protein PD 1; hPD 1; PD1; PDCD1 Location Cell membrane Accession Q15116 Clone Number S R570 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 647 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from date of
Product Specification
| Host | Mouse |
| Antigen | CD279 (PD-1) |
| Synonyms | Programmed cell death protein 1; Protein PD-1; hPD-1; PD1; PDCD1 |
| Location | Cell membrane |
| Accession | Q15116 |
| Clone Number | S-R570 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Hu |
Background
Programmed cell death protein 1 (PD-1), also known as CD279, is a type I transmembrane protein belonging to the CD28 immunoglobulin superfamily. It is encoded by the Pdcd1 gene and consists of 288 amino acids, including an extracellular IgV-like domain, a transmembrane region, and a cytoplasmic tail. PD-1 is expressed on activated T cells, B cells, macrophages, dendritic cells, and natural killer cells. Its cytoplasmic domain contains two tyrosine residues that form an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM), which play key roles in inhibiting T cell receptor signaling. PD-1 interacts with its ligands PD-L1 and PD-L2 to negatively regulate immune responses, contributing to peripheral tolerance and preventing autoimmune diseases. However, this inhibitory function can also suppress anti-tumor immunity, making PD-1 a promising target for cancer immunotherapy.
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