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Description
GLS1 Recombinant Rabbit mAb (S-2355-20)Product Specification Host Rabbit Antigen GLS1 Synonyms Glutaminase kidney isoform, mitochondrial; K glutaminase; L glutamine amidohydrolase; KIAA0838; GLS Immunogen Synthetic Peptide Location Cytoplasm, Mitochondrion Accession O94925 Clone Number S 2355 20 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu Positive Sample HeLa, 293T, A549 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | GLS1 |
| Synonyms | Glutaminase kidney isoform, mitochondrial; K-glutaminase; L-glutamine amidohydrolase; KIAA0838; GLS |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Mitochondrion |
| Accession | O94925 |
| Clone Number | S-2355-20 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu |
| Positive Sample | HeLa, 293T, A549 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu |
| IHC-P | 1:200 | Hu |
| ICC | 1:500 | Hu |
Background
GLS1, or glutaminase 1, is a mitochondrial enzyme that catalyzes the conversion of glutamine to glutamate and ammonia. It plays a crucial role in various physiological and pathological processes. In the central nervous system, GLS1 is essential for synaptic transmission and neurogenesis, as it provides the key excitatory neurotransmitter glutamate. In cancer, GLS1 is often upregulated and promotes tumor cell proliferation, survival, and metastasis by fueling the tricarboxylic acid (TCA) cycle. Additionally, in endothelial cells, GLS1 supports cell proliferation and migration through the regulation of cell cycle progression and reactive oxygen species production.
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