SKU: 68609897295

MAPKAPK-2 Recombinant Rabbit mAb (S-2641-58)

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Description

MAPKAPK-2 Recombinant Rabbit mAb (S-2641-58)Product Specification Host Rabbit Antigen MAPKAPK 2 Synonyms MAP kinase activated protein kinase 2; MAPK activated protein kinase 2; MAPKAP kinase 2; MAPKAP K2; MK 2; MK2; MAPKAPK2 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession P49137 Clone Number S 2641 58 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt, Mk Positive Sample HeLa treated with UV (100 mJ cm2, 1 hour recovery), 293T, A431, NIH 3T3, MEF,

Product Specification


Host Rabbit
Antigen MAPKAPK-2
Synonyms MAP kinase-activated protein kinase 2; MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAP-K2; MK-2; MK2; MAPKAPK2
Immunogen Synthetic Peptide
Location Cytoplasm, Nucleus
Accession P49137
Clone Number S-2641-58
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu, Ms, Rt, Mk
Positive Sample HeLa treated with UV (100 mJ/cm2, 1 hour recovery), 293T, A431, NIH/3T3, MEF, mouse brain, mouse spleen, C6, rat brain, rat spleen, COS-7
Predicted Reactivity Hm, Rb
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000-1:2000 Hu, Ms, Rt, Mk

Background

MAPKAPK-2 (commonly referred to as MK2) is a serine/threonine protein kinase encoded by the MAPKAPK2 gene and serves as the most pivotal direct substrate of p38 MAPK, acting as a signaling hub in inflammation, tumorigenesis, the DNA damage response, and cellular senescence. In its resting state, MK2 remains inactive due to an autoinhibitory conformation formed between its C-terminal regulatory domain and its kinase domain. Upon exposure to cellular stress, inflammatory cytokines, or pathogen stimulation, p38α phosphorylates MK2 at Thr334, triggering a conformational switch that simultaneously exposes a nuclear export signal (NES) —promoting p38-bound MK2 translocation to the cytoplasm—and masks its C-terminal nuclear localization signal (NLS) , thereby directing p38 signaling precisely toward cytoplasmic targets. Activated MK2 executes pleiotropic functions via phosphorylation of a diverse substrate repertoire: in the cytoplasm, it phosphorylates HSP27 to remodel the actin cytoskeleton and facilitate cell migration; in RNA metabolism, it phosphorylates ARE-binding proteins such as Tristetraprolin (TTP) and hnRNP A0, causing their 14-3-3-mediated sequestration and inactivation, thereby stabilizing the mRNAs of pro-inflammatory cytokines including TNF-α, IL-6, and IL-1β—a core mechanism driving chronic inflammation. Within the nucleus, MK2 phosphorylates transcription factors such as CREB and SRF, and contributes to maintaining the G2/M checkpoint by regulating the stability of GADD45A mRNA following DNA damage. Recent studies have expanded the functional landscape of MK2 far beyond the classical inflammatory axis: within the tumor microenvironment, MK2 promotes cell survival, drives epithelial-mesenchymal transition (EMT), and confers chemoresistance (e.g., desensitizing pancreatic cancer to gemcitabine and tongue squamous cell carcinoma to paclitaxel), positioning it as a promising target for overcoming drug resistance. In senescent cells, the mTOR pathway selectively upregulates MK2 translation via 4EBP1; the accumulated MK2 then phosphorylates ZFP36L1, relieving its degradation of SASP component mRNAs and thereby establishing the senescence-associated secretory phenotype (SASP).

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SKU: 68609897295

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