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Description
PE Mouse Anti-Human CD169 Antibody (S-2972)Product Specification Host Mouse Antigen CD169 Synonyms Sialoadhesin; Sialic acid binding Ig like lectin 1 (Siglec 1); SN; SIGLEC1 Location Cell membrane Accession Q9BZZ2 Clone Number S 2972 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human peripheral blood monocyte derived dendritic cells Purification Protein G Concentration 0. 2 mg ml Conjugation PE Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3%
Product Specification
| Host | Mouse |
| Antigen | CD169 |
| Synonyms | Sialoadhesin; Sialic acid-binding Ig-like lectin 1 (Siglec-1); SN; SIGLEC1 |
| Location | Cell membrane |
| Accession | Q9BZZ2 |
| Clone Number | S-2972 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human peripheral blood monocyte-derived dendritic cells |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | PE |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD169 (also called Siglec-1 or sialoadhesin) is a 175 kDa type I transmembrane glycoprotein of the immunoglobulin superfamily expressed predominantly by subsets of tissue-resident macrophages and some dendritic cells; it contains 17 extracellular Ig-like domains whose distal V-set domain binds α2,3-linked sialic acids on host glycoproteins and glycolipids or on pathogens, enabling cell–cell and cell–matrix adhesion during inflammation, pathogen capture (e.g., PRRSV, SARS-CoV-2), antigen presentation, and modulation of innate and adaptive immunity, while its expression is up-regulated by interferons and correlates with disease activity in infections, inflammatory disorders, and cancer where CD169⁺ macrophages in tumor-draining lymph nodes are associated with better prognosis.
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