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Description
Olfactory Marker/OMP Recombinant Rabbit mAb (S-3513-32)Product Specification Host Rabbit Antigen Olfactory Marker OMP Synonyms Olfactory marker protein; Olfactory neuronal specific protein; OMP Immunogen Recombinant Protein Location Cytoplasm Accession P47874 Clone Number S 3513 32 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, IF Reactivity Ms, Rt Positive Sample mouse olfactory bulb, rat olfactory bulb Purification Protein A Concentration 0. 25 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | Olfactory Marker/OMP |
| Synonyms | Olfactory marker protein; Olfactory neuronal-specific protein; OMP |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm |
| Accession | P47874 |
| Clone Number | S-3513-32 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, IF |
| Reactivity | Ms, Rt |
| Positive Sample | mouse olfactory bulb, rat olfactory bulb |
| Purification | Protein A |
| Concentration | 0.25 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms, Rt |
| IHC-P | 1:1000 | Ms, Rt |
| IF | 1:250 | Ms, Rt |
Background
Olfactory Marker Protein (OMP) is a small, ~19 kDa cytosolic protein uniquely and abundantly expressed in mature olfactory receptor neurons (ORNs) across the vertebrate olfactory epithelium, from the cell soma to the distal axon terminals in the olfactory bulb, where it was first discovered by Frank Margolis in the 1970s as a specific molecular signature for terminally differentiated olfactory neurons. Although its precise physiological function remains incompletely understood, OMP is believed to modulate olfactory signal transduction by interacting with odorant receptor signaling cascades, regulating cAMP kinetics, and potentially facilitating odorant adaptation, while also playing roles in axon guidance, synaptic targeting, and the refinement of olfactory maps during development and regeneration. As the definitive immunohistochemical marker for mature ORNs, OMP distinguishes fully differentiated neurons from immature (expressing GAP43) and sustentacular cells, making it indispensable for studying neuronal turnover, lesion-induced regeneration, and the functional anatomy of the olfactory system in both normal and pathological states, including neurodegenerative diseases and post-viral olfactory dysfunction.
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