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Description
Human BACE2 Protein, His TagProduct Specification Species Human Synonyms Beta secretase 2, Aspartic like protease 56 kDa, Aspartyl protease 1 (ASP1; Asp 1), Beta site amyloid precursor protein cleaving enzyme 2 (Beta site APP cleaving enzyme 2), Down region aspartic protease (DRAP), Memapsin 1, Membrane associated aspartic protease 1, Theta secretase, AEPLC, ALP56, ASP21 Accession Q9Y5Z0 Amino Acid Sequence Protein sequence (Q9Y5Z0, Ala21 Pro466, with C His Tag)
Product Specification
| Species | Human |
| Synonyms | Beta-secretase 2, Aspartic-like protease 56 kDa, Aspartyl protease 1 (ASP1; Asp 1), Beta-site amyloid precursor protein cleaving enzyme 2 (Beta-site APP cleaving enzyme 2), Down region aspartic protease (DRAP), Memapsin-1, Membrane-associated aspartic protease 1, Theta-secretase, AEPLC, ALP56, ASP21 |
| Accession | Q9Y5Z0 |
| Amino Acid Sequence | Protein sequence (Q9Y5Z0, Ala21-Pro466, with C-His Tag) APELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGLALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEP |
| Expression System | HEK293 |
| Molecular Weight | Predicted MW: 49.6 kDa Observed MW: 55 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. |
Background
Beta-secretase 2 (BACE2) is an aspartic protease encoded by a gene located on chromosome 21. It is expressed in various peripheral tissues and, to a lesser extent, in the central nervous system. Unlike its role in amyloid precursor protein (APP) processing, BACE2 primarily cleaves APP within the amyloid-beta domain, an action that may limit amyloid-beta peptide production. Its physiological functions extend to processes such as pancreatic beta-cell maintenance, skin pigmentation regulation, and skeletal muscle homeostasis. Research into BACE2 is also significant in the context of Down syndrome, due to the gene dosage effect associated with its chromosomal location.
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