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Description
Fc gamma RIIIa/CD16a Mouse mAb (S-564-39)Product Specification Host Mouse Antigen Fc gamma RIIIa CD16a Synonyms Low affinity immunoglobulin gamma Fc region receptor III A, IgG Fc receptor III A, CD16 II, CD16a antigen, Fc gamma RIII alpha, Fc gamma RIII, FcRIII, FcRIIIa, FcgammaRIIIA, FcR 10, IgG Fc receptor III 2, FCGR3A, FCG3, FCGR3, IGFR3 Immunogen Synthetic Peptide Location Secreted, Cell membrane Accession P08637 Clone Number S 564 39 Antibody Type Mouse mAb Isotype IgG1,k Application
Product Specification
| Host | Mouse |
| Antigen | Fc gamma RIIIa/CD16a |
| Synonyms | Low affinity immunoglobulin gamma Fc region receptor III-A, IgG Fc receptor III-A, CD16-II, CD16a antigen, Fc-gamma RIII-alpha, Fc-gamma RIII, FcRIII, FcRIIIa, FcgammaRIIIA, FcR-10, IgG Fc receptor III-2, FCGR3A, FCG3, FCGR3, IGFR3 |
| Immunogen | Synthetic Peptide |
| Location | Secreted, Cell membrane |
| Accession | P08637 |
| Clone Number | S-564-39 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300/ |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | null |
Background
CD16 has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b), which participate in signal transduction. The most well-researched membrane receptor implicated in triggering lysis by NK cells, CD16 is a molecule of the immunoglobulin superfamily (IgSF) involved in antibody-dependent cellular cytotoxicity (ADCC). It can be used to isolate populations of specific immune cells through fluorescent-activated cell sorting (FACS) or magnetic-activated cell sorting, using antibodies directed towards CD16. CD16 plays a significant role in early activation of natural killer (NK) cells following vaccination. In addition, CD16 downregulation represents a possible way to moderate NK cell responses and maintain immune homeostasis in both T cell and antibody-dependent signaling pathways.
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